Skip to main content

Advertisement

SpringerLink
Log in

Improving the Quality of Medicinal Products by a Microencapsulation Method

  • Published:
Pharmaceutical Chemistry Journal Aims and scope

The possibility of the enhancing the bioavailability, increasing the shelf life, and improving the organoleptic properties of finished pharmaceuticals using microencapsulation is reviewed. Predetermined properties, including gradual supply of the active ingredient into the blood pool, can be highly reliably provided.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Notes

  1. Actilease® microcapsules contain very fine particles of the active ingredients (lutein and zeaxanthin) in a special protective water-soluble shell. The protective sell is dissolved in vivo. The microcapsules of active ingredient are readily released, leading to maximum absorption of lutein and zeaxanthin. The microcapsules protect lutein and zeaxanthin from oxygen, metal ions, radicals, and residual destructive factors, which allows the micronutrients to remain useful for the whole shelf life.

References

  1. B. Coyne, J. Faragher, et al., “Microcapsules,” RU Pat. No. 2,359,662, Jun. 27, 2009.

  2. A. Rehor, L. Canaple, Z. Zhang, and D. Hunkeler, J. Biomater. Sci., Polym. Ed., 12(2), 157 – 170 (2001).

  3. I. Katouzian, E. A. Faridi, S. M. Jafari, and S. Akhavan, Trends Food Sci. Technol., 68 (Suppl. C), 14 – 25 (2017).

  4. I. Katouzian and S. M. Jafari, Trends Food Sci. Technol., 53, 34 – 48 (2016).

    Article  CAS  Google Scholar 

  5. P. Kaushik, K. Dowling, C. J. Barrow, and B. Adhikari, J. Funct. Foods, 19, Part B, 868 – 881 (2015).

  6. N. V. Avtina, Nauchn. Vedom. Belgorod. Gos. Univ. Med. Farm., 99(4), No. 13, 170 – 176 (2011).

  7. N. V. Avtina, Sovrem. Probl. Nauki Obraz., No. 4 (2012); www.science-education.ru / 104 – 6650 (accessed Apr. 21, 2014).

  8. E. E. Bykovskaya and A. A. Krolevets, “Method for preparing microcapsules,” RU Pat. Appl. No. 2012110715 / 15, Sept. 27, 2013.

  9. E. K. Bae and S. J. Lee, J. Microencapsulation, 25(8), 549 – 560 (2008).

    Article  CAS  Google Scholar 

  10. G. G. Anilkumar, V. Niraj, R. K. Atul, and S. Robert, Microencapsulation in the Food Industry, Academic Press, San Diego, USA (2014).

  11. E. E. Bykovskaya and A. A. Krolevets, “Method for preparing cephalosporin microcapsules,” RU Pat. Appl. No. 2012109496 / 15, Sept. 20, 2013.

  12. M. Calanchi, L. Gentilini, and M. Marconi, “Method of microcapsulated composition producing,” RU Pat. No. 2,059,409, May 10, 1996.

  13. M. Schneider and P. Bussat, “Microcapsules, method for preparation and their use,” RU Pat. No. 96117128 / 14 (1995).

  14. Ya. V. Postrash and O. M. Khishova, Vestn. Farm., 48(2), 1 – 7 (2010).

  15. M. Corgneau, C. Gaiani, J. Petit, et al., Int. J. Food Sci. Technol., 54, 2586 – 2594 (2019).

    Article  CAS  Google Scholar 

  16. G. Spaggiari, A. Di Pizio, and P. Cozzini, Trends Food Sci. Technol., 96(2), 21 – 29 (2020).

    Article  CAS  Google Scholar 

  17. H. X. Niu, J. Chang, and Y. D. Jia, Mater. Res. Innovations, 19(5), S5 – 257–S5 – 262 (2015).

  18. J. T. Chung, K. D. F. Vlugt-Wensink, W. E. Hennink, and Z. Zhang, Int. J. Pharm., 288(1), 51 – 61 (2005).

    Article  CAS  Google Scholar 

  19. S. Polavarapu, M. C. Oliver, S. Ajlouni, and A. M. Augustin, J. Food Eng., 127(4), 1694 – 1705 (2011).

    CAS  Google Scholar 

  20. P. Calvo, T. Hernandez, M. Lozano, and D. Gonzalez-Gomez, Eur. J. Lipid Sci. Technol., 112, 852 – 858 (2010).

    Article  CAS  Google Scholar 

  21. A. Fery and R. Weinkamer, Polymer, 48, 7221 – 7235 (2007).

    Article  CAS  Google Scholar 

  22. L. Sanguansri, M. A. Augustin, T. J. Lockett, et al., Br. J. Nutr., 113(5), 822 – 831 (2015).

    Article  CAS  Google Scholar 

  23. M. A. Augustin and L. Sanguansri, December, in: Oxidation in Foods and Beverages and Antioxidant Applications, Woodhead Publishing (2010), pp. 479 – 495.

  24. M. A. Augustin, L. Sanguansri, and O. Bode, J. Food Sci., 71(2), E25-E32 (2006).

    Article  CAS  Google Scholar 

  25. R. Mercade-Prieto and Z. Zhang, J. Microencapsulation, 29(3), 277 – 285 (2012).

    Article  CAS  Google Scholar 

  26. W. Schalch, W. Cohn, F. M. Barker, et al., Arch. Biochem. Biophys., 458(2), 128 – 135 (2007).

    Article  CAS  Google Scholar 

  27. Q. Xia, T. O. Akanbi, B. Wang, et al., Mar. Drugs, 17(3), 143 (2019).

    Article  CAS  Google Scholar 

  28. D. Hartmann, P. A. Thurmann, V. Spitzer, et al., Am. J. Clin. Nutr., 79(3), 410 – 417 (2004).

    Article  CAS  Google Scholar 

  29. P. A. Thurmann,W. Schalch, J. C. Aebischer, et al., Am. J. Clin. Nutr., 82(1), 88 – 97 (2005).

    Article  Google Scholar 

  30. S. Arslan-Tontul and M. Erbas, LWT – Food Sci. Technol., 81, 160 – 169 (2017).

    CAS  Google Scholar 

  31. C. R. L. Francisco, S. A. Heleno, I. P. M. Fernandes, et al., Food Chem., 245, 845 – 853 (2018).

    Article  CAS  Google Scholar 

  32. D. Kavitake, S. Kandasamy, P. B. Devi, and P. H. Shetty, Food Biosci., 21, 34 – 44 (2018).

    Article  CAS  Google Scholar 

Download references

Acknowledgments

The article was sponsored by the Strategic Academic Leadership Program of People’s Friendship University of Russia.

Author information

Authors and Affiliations

  1. People’s Friendship University of Russia, 6 Miklukho-Maklaya St., Moscow, 117198, Russia

    S. V. Orlova & E. A. Nikitina

  2. DSM Nutritional Products AG, 4303, Kaiseraugst, Switzerland

    D. V. Karpukhin

  3. DSM Eastern Europe, Moscow, 129226, Russia

    T. E. Nekrasova

Authors
  1. S. V. Orlova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. A. Nikitina
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. V. Karpukhin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T. E. Nekrasova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to S. V. Orlova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 12, pp. 48 – 51, December, 2020.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Orlova, S.V., Nikitina, E.A., Karpukhin, D.V. et al. Improving the Quality of Medicinal Products by a Microencapsulation Method. Pharm Chem J 54, 1278–1281 (2021). https://doi.org/10.1007/s11094-021-02355-7

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-021-02355-7

Keywords

Search

Navigation