Experiments on cell cultures addressed the antiviral properties of 2-anilino-4,6-di-tert-butylphenol and N-(3,5-di-tert-2-hydroxyphenyl)acetamide, both of which are o-aminophenol derivatives, and 3,4-dihydroxy-benzoic acid against herpes simplex virus and in experimental cutaneous herpes in white mice. Assessment of the data obtained here indicates that all three study compounds were significantly less active than acyclovir in cell cultures. In experiments on laboratory animals, the efficacy of ointment containing N-(3,5-di-tert-2-hydroxyphenyl) acetamide was comparable with that of acyclovir ointment, while ointments containing 2-anilino-4,6-di-tert-butylphenol and 3,4-dihydroxybenzoic acid were less active.
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References
E. De Clercq, Clin. Microbiol. Rev., 10(4), 674 – 930 (1997).
B. Halliwell, and J. M. C. Gutteridge, Free Radicals in Biology and Medicine, Oxford University press, Oxford (2012), pp. 609 – 613.
O. I. Shadyro, G. A. Ksendzova, G. I. Polozov, et al., Bioorg. Med. Chem. Let., 18(7), 2420 – 2423 (2008).
O. I. Shadyro, V. L. Sorokin, G. A. Ksendzova, et al., Khim.-Farm. Zh., 46(7), 27 – 30 (2012); Pharm. Chem. J., 46(7), 414 – 417 (2012).
Patent of the Republic of Belarus 11933; Afitsyiny Byul. Nats. Tséntra Intélekt. Ulasnastsi, No. 3, 42 (2009).
Patent of the Republic of Belarus 17000; Afitsyiny Byul. Nats. Tséntra Intélekt. Ulasnastsi, No. 2, 56 – 57 (2013).
S. N. Samovich, S. D. Brinkevich, and O. I. Shadyro, Rad. Phys. Chem., 82(1), 35 – 43 (2013).
G. A. Ksendzova, V. L. Sorokin, I. P. Edimecheva, and O. I. Shadyro, Free Radic Res., 38(11), 1183 – 1190 (2004).
O. I. Shadyro, V. L. Sorokin, G. A. Ksendzova, et al., Khim.-Farm. Zh., 36(8), 14 – 16 (2002); Pharm. Chem. J., 36(8), 410 – 412 (2012).
O. I. Shadyro, V. L. Sorokin, G. A. Ksendzova, et al., Khim.-Farm. Zh., 37, No. 8, 5 – 7 (2003); Pharm. Chem. J., 37, No. 8, 399 – 401 (2003).
E. I. Boreko, N. I. Pavlova, G. V. Zaitseva, and I. A. Mikhailopulo, Vopr. Virusol., No. 5, 40 – 42 (2001).
K. P. Fung, Comput. Biol. Med., 19, No. 2, 131 – 135 (1989).
M. R. Boyd, T. N. Bacon, and D. Sutton, Antimicrob. Agent Chemother, 32(1), 358 – 363 (1988).
E. I. Boreko, O. V. Savinova, N. I. Pavlova, et al., “Current problems in infectious pathology in humans (epidemiology, clinical features, virology, microbiology, and immunology)” [in Russian], in: Proceedings of the Science Research Institute of Epidemiology and Microbiology for the State Scientific-Technical Program “Infections and Medical Biotechnology” 2001 – 2005 [in Russian], Minsk (2005), pp. 430 – 437.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 53, No. 7, pp. 45 – 48, July, 2019.
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Shadyro, O.I., Sorokin, V.L., Ksendzova, G.A. et al. Comparative Evaluation of the Antiherpes Activity of Compounds with Different Mechanisms of Action. Pharm Chem J 53, 646–649 (2019). https://doi.org/10.1007/s11094-019-02055-3
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DOI: https://doi.org/10.1007/s11094-019-02055-3