Hepatitis C virus (HCV) is the leading cause of chronic liver disease, surpassing hepatitis B virus and alcohol. The paradigm for treating HCV has radically changed over the last 20 years. The tolerability and duration of treating HCV patients was altered fundamentally by the emergence of modern and more efficacious treatment regimens and plans. Nevertheless, the risk of developing serious adverse reactions, including those due to drug–drug interactions, remains high. Currently, eight drugs are approved for treating HCV and avoid the use of interferons. The present article reviews these drugs with respect to their efficacy and safety for use in patients with various HCV genotypes.
Similar content being viewed by others
References
Global Hepatitis Report 2017, World Health Organization, Geneva (2017); http://apps.who.int/iris/bitstream/10665/255016/1/9789241565455-eng.pdf?ua=1 (accessed Feb. 19, 2018).
A. I. Gubenko and N. N. Eremenko, Vedom. Nauchn. Tsentra Ekspertizy Sredstv Med. Primeneniya, No. 4, 22 – 25 (2013).
A. Binkley and N. S. Pandit, Pharmacy Times, July (2017); http://www.pharmacytimes.com/publications/issue/2017/july2017/hepatitis-c-treatment (accessed Feb. 19, 2018).
I. I. Snegireva, E. Yu. Pasternak, K. E. Zatolochina, et al., Besop. Risk Farmakoter., 5(4), 161 – 169 (2017).
N. Tikhonova, T. Lopatkina, and A. Odintsov, Vrach, No. 8, 30 – 33 (2013).
A. V. Vedernikova, M. V. Maevskaya, V. T. Ivashkin, et al., Ross. Zh. Gastroenterol., Gepatol., Koloproktol., 17(2), 40 – 49 (2007).
N. D. Yushchuk, O. O. Znoiko, K. R. Dudina, et al., Ter. Arkh., 88(6), 101 – 105 (2016).
HCV Guidance: Recommendations for Testing, Managing, and Treating Hepatitis C, American Association for the Study of Liver Diseases, Infectious Diseases Society of America; hcvguidelines.org (accessed Feb. 19, 2018).
A. S. Kazakov, R. N. Alyautdin, I. I. Snegireva, et al., Eksp. Klin. Farmakol., 80(3), 36 – 39 (2017).
J. L. Horsley-Silva and H. E. Vargas, Gastroenterol. Hepatol., 13(1), 22 – 31 (2017).
S. Zeuzem, M. Mizokami, S. Pianko, et al., J. Hepatol., 66(5), 910 – 918 (2017).
J. L. Romine, ACS Med. Chem. Lett., 2(3), 224 – 229 (2011).
A. P. Rote, J. Alhat, and A. A. Kulkarni, Int. J. Pharm. Sci. Drug Res., 9(6), 291 – 298 (2017).
J. J. Feld, I. M. Jacobson, C. Hezode, et al., N. Engl. J. Med., 373(27), 2599 – 2607 (2015).
G. R. Foster, E. Gane, A. Asatryan, et al., J. Hepatol., 66, No. 1, S33 (2017).
J. J. Kohler, J. H. Nettles, F. Amblard, et al., Infect. Drug Resist., No. 7, 41 – 56 (2014).
J. J. Feld, K. V. Kowdley, E. Coakley, et al., N. Engl. J. Med., 370, 1594 – 1603 (2014).
A. Abergel, T. Asselah, S. Metivier, et al., Lancet Infect. Dis., 16(4), 459 – 464 (2016).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 6, pp. 9 – 12, June, 2018.
Rights and permissions
About this article
Cite this article
Kazakov, A.S., Lepakhin, V.K., Bukatina, T.M. et al. Efficacies and Chemical Structures of Modern Drugs for Hepatitis C Virus Treatment. Pharm Chem J 52, 497–500 (2018). https://doi.org/10.1007/s11094-018-1847-9
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11094-018-1847-9