We present here a review of published data mostly from the last 10 years on the antitumor activity of substances from the fungus Ganoderma lucidum. Its main biologically active components are described, particularly triterpenes, polysaccharides, glycoproteins, and proteoglycans. The mechanisms of the antitumor actions of these compounds in vitro and in vivo are discussed, these including blockade of the cell cycle, induction of apoptosis, decreases in the metastatic potential, suppression of angiogenesis, and immunomodulatory activity. The potential of using substances from G. lucidum for the treatment of oncological patients is assessed.
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References
B. Boh, M. Berovic, J. Zhang, and L. Zhi-Bin, Biotechnol. Annu. Rev., 13, 265 – 301 (2007).
X. Zhou, J. Lin, Y. Yin, et al., Am. J. Chin. Med., 35(4), 559 – 574 (2007).
K. Haralampidis, M. Trojanowska, and A. E. Osbourn, Adv. Biochem. Eng. Biotechnol., 75, 31 – 49 (2002).
S. Wachtel-Galor, J. Yuen, J. A. Buswell, and I. F. F. Benzie, in: Herbal Medicine: Biomolecular and Clinical Aspects, S. Wachtel- Galor and I. F. F. Benzie (eds.), CRC Press / Taylor & Francis, Boca Raton (2011), Ch. 9.
J. Zhang, Q. Tang, C. Zhou, et al., Life Sci., 87(19 – 22), 628 – 637 (2010).
A. Jedinak, A. Thyagarajan-Sahu, J. Jiang, and D. Sliva, Int. J. Oncol., 38(3), 761 – 767 (2011).
G. Wang, J. Zhao, J. Liu, et al., Int. Immunopharmacol., 7(6), 864 – 870 (2007).
C. J. Weng, C. F. Chau, G. C. Yen, et al., J. Agric. Food Chem., 57(11), 5049 – 5057 (2009).
G. S. Wu, J. J. Lu, J. J. Guo, et al., Fitoterapia, 83(2), 408 – 414 (2012).
H. L. Yang, Biotechnol. Lett., 27(12), 835 – 838 (2005).
S. B. Lin, C. H. Li, S. S. Lee, and L. S. Kan, Life Sci., 72(21), 2381 – 2390 (2003).
R. M. Liu and J. J. Zhong, Phytomedicine, 18(5), 349 – 355 (2011).
J. K. Brunelle and A. Letai, J. Cell Sci., 122(4), 437 – 441 (2009).
A. A. Fil’chenkov, Biomed. Khim., 59(2), 119 – 143 (2013).
Z. Ji, Q. Tang, R. Hao, et al., Oncol. Let., 2(3), 565 – 570 (2011).
C. H. J. Kao, A. C. Jesuthasan, K. S. Bishop, et al., Funct. Foods Health Dis., 3(2), 48 – 65 (2013).
C. L. Hsu, Y. S. Yu, and G. C. Yen, J. Agric. Food Chem., 56(11), 3973 – 3980 (2008).
J. Loganathan, J. Jiang, A. Smith, et al., Int. J. Oncol., 44(6), 2009 – 2015 (2014).
C. J. Weng and G. C. Yen, Clin. Exp. Metastasis, 27(5), 361 – 369 (2010).
A. Thyagarajan, J. Jiang, A. Hopf, et al., Int. J. Mol. Med., 18(4), 657 – 664 (2006).
G. S. Wu, Y. L. Song, Z. Q. Yin, et al., PloS One, 8(10), e76620 (2013).
N. H. Chen and J. J. Zhong, Phytomedicine, 18(8 – 9), 719 – 725 (2011).
C. J. Weng, C. F. Chau, Y. S. Hsieh, et al., Carcinogenesis, 29(1), 147 – 156 (2008).
I. C. Ferreira, S. A. Heleno, F. S. Reis, et al., Phytochemistry, 114, 38 – 55 (2015).
J. Lu, L. X. Sun, Z. B. Lin, et al., Phytother. Res., 28(2), 200 – 206 (2013).
M. K. Srivastava, A. Andersson, L. Zhu, et al., Immunotherapy, 4(3), 291 – 304.
L. X. Sun, W. D. Li, Z. B. Lin, et al., Cell. Physiol. Biochem., 33(2), 289 – 299 (2014).
S. Y. Wang, M. L. Hsu, H. C. Hsu, et al., Int. J. Cancer, 70(6), 699 – 705 (1997).
S. Cheng and D. Sliva, Integr. Cancer Ther., 14(3), 249 – 257 (2015).
X. Pang, Z. Chen, X. Gao, et al., J. Food Sci., 72(6), 435 – 442 (2007).
P. Y. Wang, X. L. Zhu, and Z. B. Lin, Front. Pharmacol., 3(135), (2012).
S. F. Liao, C. H. Liang, M. Y. Ho, et al., Proc. Natl. Acad. Sci. USA, 110(34), 13809 – 13814 (2013).
Z. Liang, Y. T. Guo, Y. J. Yi, et al., Asian. Pac. J. Cancer Prev., 15(9), 3981 – 3986 (2014).
Z. Liang, Y. Yi, Y. Guo, et al., Int. J. Mol. Sci., 15(5), 9103 – 9116 (2014).
Z. E. Liang, Y. J. Yi, Y. T. Guo, et al., Mol. Med. Rep., 12(5), 7629 – 7636 (2015).
Z. Sun, K. Huang, X. Fu, et al., Tumour Biol., 35(10), 9919 – 9926 (2014).
D. Shang, Y. Li, C. Wang, et al., Oncol. Rep., 25(1), 267 – 272 (2011).
Q. Z. Cao and Z. B. Lin, Life Sci., 78(13), 1457 – 1463 (2006).
G. Stanley, K. Harvey, V. Slivova, et al., Biochem. Biophys. Res. Commun., 330(1), 46 – 52 (2005).
J. J. Li, L. S. Lei, C. L. Yu, et al., Nan Fang Yi Ke Da Xue Xue Bao, 27(7), 1003 – 1005 (2007).
J. Wang, L. Zhang, Y. Yu, and P. C. Cheung, J. Agric. Food Chem., 57(22), 10565 – 72 (2009).
Y. Y. Wang, K. H. Khoo, S. T. Chen, et al., Bioorg. Med. Chem., 10(4), 1057 – 1062 (2002).
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 1, pp. 33 – 38, January, 2018.
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Petrova, E.S., Rudina, M.I. & Shvarts, Y.S. Antitumor Potential of Substances from the Fungus Ganoderma lucidum. Pharm Chem J 52, 57–62 (2018). https://doi.org/10.1007/s11094-018-1765-x
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DOI: https://doi.org/10.1007/s11094-018-1765-x