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Preparation, Toxicity, and Anti-Inflammatory Activity of Complexes of Uracil Derivatives with Polyfunctional Acids

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Pharmaceutical Chemistry Journal Aims and scope

Uracil derivatives (6-methyluracil, 5-hydroxy-6-methyluracil) and polyfunctional acids (citrus pectin, oxidized fraction of citrus pectin, and 5-aminosalicylic acid) were shown to form rather stable 1:1 complexes, i.e., one uracil molecule for each carboxylic acid of the polyfunctional acid. Synthetic methods for these complexes were developed based on the results. Their toxicity and anti-inflammatory activity were studied. It was established that complexes of 6-methyluracil with the oxidized fraction of citrus pectin and of 5-hydroxy-6-methyluracil with 5-aminosalicylic acid possessed low toxicity and high anti-inflammatory activity.

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Acknowledgments

The work was sponsored by Project No. 4.299.2014/K under the project part of an RF Ministry of Education and Science State Contract for Scientific Activities and an RFBR grant (Project 14-03-97026 r povolzh’e a).

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Authors and Affiliations

  1. Bashkir State University, Ufa, Bashkortostan, 452750, Russia

    Yu. S. Zimin, N. S. Borisova & A. G. Mustafin

  2. Branch of Ufa State Aviation Technical University, Tuimazy, Bashkortostan, 452750, Russia

    G. R. Timerbaeva

  3. Institute of Chemistry, Ufa Scientific Center, Russian Academy of Sciences, Ufa, Bashkortostan, 450054, Russia

    A. R. Gimadieva & A. G. Mustafin

Authors
  1. Yu. S. Zimin
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  2. N. S. Borisova
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  3. G. R. Timerbaeva
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  4. A. R. Gimadieva
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  5. A. G. Mustafin
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 50, No. 10, pp. 22 – 26, October, 2016.

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Zimin, Y.S., Borisova, N.S., Timerbaeva, G.R. et al. Preparation, Toxicity, and Anti-Inflammatory Activity of Complexes of Uracil Derivatives with Polyfunctional Acids. Pharm Chem J 50, 649–653 (2017). https://doi.org/10.1007/s11094-017-1507-5

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  • DOI: https://doi.org/10.1007/s11094-017-1507-5

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