N-Aryl(hetaryl)methylidene-4-[9-(thio)xanthenyl]anilines, N-arylmethylidene-{4-(5H-chromeno[2,3-b]pyridin-5-yl)phenyl}amines, and N-aryl(hetaryl)methyl-4-[9-(thio)xanthenyl]anilines were synthesized via the reaction of imines and amines with xanthydrol, thioxanthydrol, and 1-azaxanthydrol and exhibited antibacterial activity with respect to S. aureus No. 906 and E. coli No. 1257. Six museum and five hospital microorganism strains and three compounds that exhibited earlier high biological activity against three cultures (S. aureus No. 906, E. coli No. 1257, and C. albicans No. 24433) were tested in an expanded study.
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Acknowledgments
We thank G. A. Aleksandrova, Senior Scientist of the Bactericide Research Laboratory, for studying the antibacterial activity. The work was supported financially by the Perm Krai Ministry of Education.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 50, No. 8, pp. 33 – 35, August, 2016.
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Gorokhov, V.Y., Makhova, T.V. Synthesis and Antibactericidal Activities of Amines and Imines Containing (Aza, Thio)Xanthene Rings. Pharm Chem J 50, 530–533 (2016). https://doi.org/10.1007/s11094-016-1483-1
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DOI: https://doi.org/10.1007/s11094-016-1483-1