This article reports microbial biotransformation of dexamethasone, a synthetic glucocorticoid, by Bacillus subtilis. This bacterium can be used as a microbial metabolic model to investigate the metabolism of other synthetic glucocorticoids as it mimics mammalian metabolism to a certain extent. Incubation of dexamethasone with B. subtilis for 7 days yielded three compounds identified as 6-hydroxydexamethasone, 17-oxodexamethasone, and 6-hydroxy-17-oxodexamethasone. Structure elucidation of these compounds was done using 1H-NMR and 13C-NMR spectroscopy techniques.
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Pervaiz, I., Ahmad, S., Mukhtar, M.F. et al. Microbial Biotransformation of Dexamethasone by Bacillus Subtilis (ATCC 6051). Pharm Chem J 49, 405–408 (2015). https://doi.org/10.1007/s11094-015-1294-9
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DOI: https://doi.org/10.1007/s11094-015-1294-9