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Hepatoprotective Properties of Native Humic Acids Isolated from Lowland Peat of Tomsk Region

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The hepatoprotective properties of humic acids from lowland peat of Tomsk region were studied experimentally. It was established that native humic acids of peat (HAP) exhibited pronounced hepatoprotective activity against acute CCl4 hepatitis. The results showed that intragastric injection of HAP prevented damage from CCl4 to the metabolic and morphologic parameters of rat liver. The rates of lipoxidation and destruction of hepatocyte membranes and the manifestation of cytolytic syndrome decreased substantially. Liver excretory function improved. Fibrous structures did not develop in livers of experimental animals. The hepatoprotective action of HAP may be due to their pronounced antioxidant properties.

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Authors and Affiliations

  1. Siberian State Medical University, Tomsk, 634050, Russia

    M. V. Belousov, R. R. Akhmedzhanov, M. V. Zykova, A. M. Gur’ev & M. S. Yusubov

  2. Tomsk National Research Polytechnic University, Tomsk, 634050, Russia

    R. R. Akhmedzhanov & M. S. Yusubov

Authors
  1. M. V. Belousov
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  2. R. R. Akhmedzhanov
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  3. M. V. Zykova
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  4. A. M. Gur’ev
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  5. M. S. Yusubov
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 48, No. 4, pp. 28 – 31, April, 2014.

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Belousov, M.V., Akhmedzhanov, R.R., Zykova, M.V. et al. Hepatoprotective Properties of Native Humic Acids Isolated from Lowland Peat of Tomsk Region. Pharm Chem J 48, 249–252 (2014). https://doi.org/10.1007/s11094-014-1088-5

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  • DOI: https://doi.org/10.1007/s11094-014-1088-5

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