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Immunomodulating and antistress activity of ecdysterone and turkesterone under immobilization-induced stress conditions in mice

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Pharmaceutical Chemistry Journal Aims and scope

The phytoecdysteroids ecdysterone and turkesterone isolated from Rhaponticum integrifolium and Ajuga turkestanica herbs, respectively, increase the adaptation capacity of mice under immobilization-induced stress conditions. These compounds prevent involution of the thymicolymphatic system, decrease trophic disorders in gastric mucosa, prevent an increase in the weight of adrenal glands and a decrease in them of the content of ascorbic acid and cholesterol (to a much greater degree than does T-activin), and stimulate immunogenesis in animals with experimental immune deficiency developed on the background of immobilization-induced stress.

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Authors and Affiliations

  1. Nizami Tashkent State Pedagogical University, Tashkent, Uzbekistan

    G. A. Shakhmurova

  2. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan

    V. N. Syrov & Z. A. Khushbaktova

Authors
  1. G. A. Shakhmurova
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  2. V. N. Syrov
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  3. Z. A. Khushbaktova
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Corresponding author

Correspondence to G. A. Shakhmurova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 44, No. 1, pp.9 – 11, January, 2010.

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Shakhmurova, G.A., Syrov, V.N. & Khushbaktova, Z.A. Immunomodulating and antistress activity of ecdysterone and turkesterone under immobilization-induced stress conditions in mice. Pharm Chem J 44, 7–9 (2010). https://doi.org/10.1007/s11094-010-0387-8

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  • DOI: https://doi.org/10.1007/s11094-010-0387-8

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