Abstract
A series of aroyl derivatives of 4-(2-chloroethyl)semicarbazide were designed and synthesized to explore their antiproliferative activity against human brain carcinoma (U251) and human liver carcinoma (Hepg2) cell lines. The synthesized compounds were characterized by elemental analyses and spectroscopic data. It was established that compounds in which semicarbazide fragments are substituted with a (2-indolyl)carbonyl moiety showed a higher cytotoxic activity than the corresponding benzoyl derivatives. 1-[(5-Benzyloxy-1H-indol-2-yl)carbonyl]-4-(2-chloroethyl)semicarbazide (24) showed the highest cytotoxic activity against Hepg2 (IC50= 21 µg/ml), while 4-(2-chloroethyl)-1-[(5-methoxy-1H-indol-2-yl)carbonyl]semicarbazide (23) was the most active compound against U251 (IC50 = 8 µg/ml).
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 4, pp. 12–15, May, 2007.
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El-Sadek, M.E., Aboukull, M.E., El-Sabbagh, O.I. et al. Design, synthesis and cytotoxic activity of novel 1-aroyl-4-(2-chloroethyl)semicarbazides. Pharm Chem J 41, 188–192 (2007). https://doi.org/10.1007/s11094-007-0043-0
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DOI: https://doi.org/10.1007/s11094-007-0043-0