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Synthesis and antibacterial activity of 6-ethylsulfonyl-3-acylmethylene-1,4-benzoxazin-2-ones

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Abstract

Interaction of methyl esters of acylpyruvic acids with 2-amino-4-(ethylsulfonyl)phenol in a 1: 1 molar ratio yields 6-ethylsulfonyl-3-acylmethylene-1,4-benzoxazin-2-ones. The structures of the synthesized compounds were confirmed by IR, NMR, and mass spectroscopy data. Eight compounds were tested for antibacterial activity.

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References

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Authors and Affiliations

  1. Perm State Pharmaceutical Academy, Perm, Russia

    V. L. Gein, N. A. Rassudikhina & E. V. Voronina

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  1. V. L. Gein
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  2. N. A. Rassudikhina
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  3. E. V. Voronina
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 10, pp. 32–33, October, 2006.

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Gein, V.L., Rassudikhina, N.A. & Voronina, E.V. Synthesis and antibacterial activity of 6-ethylsulfonyl-3-acylmethylene-1,4-benzoxazin-2-ones. Pharm Chem J 40, 554–556 (2006). https://doi.org/10.1007/s11094-006-0192-6

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  • DOI: https://doi.org/10.1007/s11094-006-0192-6

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