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Obtaining thyroid hormones by chemical methods based on biosynthesis modeling (a review)

  • Drug Synthesis Methods and Manufacturing Technology
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Abstract

This review considers the methods of synthesis of thyroxine and triiodothyronine, which were developed on the basis of hypothetical models of their biosynthesis in the organism. Most of such methods are based on the use of highly active derivatives of phenols or quinones (4-hydroxy-3,5-diiodophenylpyruvic acid, iodine-containing derivatives of spiro-4-epoxycyclohexadienone, 2,4,6-tri-tert-butylphenol, etc.) as arylating agents. Condensation of these compounds with 3,5-derivatives of tyrosine results in the formation of substituted diaryl esters, representing thyroid hormones or their analogs. Some of the proposed methods are highly effective and lead to high yields of thyroid hormones, which can be used as parent drug substances.

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  1. Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus

    V. P. Martinovich & O. V. Sviridov

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  1. V. P. Martinovich
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  2. O. V. Sviridov
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__________

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 9, pp. 45–49, September, 2006.

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Martinovich, V.P., Sviridov, O.V. Obtaining thyroid hormones by chemical methods based on biosynthesis modeling (a review). Pharm Chem J 40, 507–512 (2006). https://doi.org/10.1007/s11094-006-0166-8

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  • DOI: https://doi.org/10.1007/s11094-006-0166-8

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