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Pharmacological activity of 2-mercaptopyrimido[4,5-b]indole and 2-mercapto-3-formylindole derivatives

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Abstract

The pharmacological properties of two compounds with new heterocyclic structures, pyrimido[4,5-b]indole and 2-mercapto-3-formylindole, were synthesized and studied on the models of hypobaric hypoxia, toxic pulmonary edema, and acute toxic liver injury. Both chemical structures showed a combination of antihypoxant and antiinflammatory activity. In addition, 2-mercapto-3-formylindole derivatives exhibited a significant hepatoprotective effect.

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Authors and Affiliations

  1. Military-Medical Academy, St. Petersburg, Russia

    V. V. Marysheva & P. D. Shabanov

Authors
  1. V. V. Marysheva
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  2. P. D. Shabanov
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 5, pp. 17–19, May, 2006.

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Marysheva, V.V., Shabanov, P.D. Pharmacological activity of 2-mercaptopyrimido[4,5-b]indole and 2-mercapto-3-formylindole derivatives. Pharm Chem J 40, 251–253 (2006). https://doi.org/10.1007/s11094-006-0103-x

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  • DOI: https://doi.org/10.1007/s11094-006-0103-x

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