Abstract
The synthesis of thymine-containing monomers of negatively charged peptide nucleic acids from L-glutamic acid derivatives is described. Two approaches to the pseudopeptide backbone creation have been realized via (i) the reaction of reductive N-alkylation and (ii) the Mitsunobu condensation reaction. It is shown that the latter pathway is more favorable.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 39, No. 6, pp. 39 – 43, June, 2005.
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Prokhorov, D.I., Kirillova, Y.G., Boyarskaya, N.P. et al. Synthesis of Thymine-Containing Monomers of Negatively Charged Peptide Nucleic Acids. Pharm Chem J 39, 323–328 (2005). https://doi.org/10.1007/s11094-005-0145-5
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DOI: https://doi.org/10.1007/s11094-005-0145-5