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Optimization of the Composition and Wet Granulation Technology of Drotaverine Hydrochloride Tablets

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Abstract

The process of drotaverine hydrochloride decomposition is modeled using data on the drug solution stability and the variation of RGB color coordinates of drotaverine hydrochloride tablets. The introduction of an acid into the drug composition ensures obtaining high-quality tablets of yellow-green color. The pressing of granules with dimensions below 0.6 mm and a relative humidity above 1.8% provides for a uniform coloration of tablets.

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Authors and Affiliations

  1. Ural Institute of Medicinal Preparation Technology, Yekaterinburg, Russia

    A. S. Gavrilov, E. V. Gusel'nikova & A. Yu. Petrov

Authors
  1. A. S. Gavrilov
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  2. E. V. Gusel'nikova
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  3. A. Yu. Petrov
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 39, No. 5, pp. 49 – 52, May, 2005.

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Gavrilov, A.S., Gusel'nikova, E.V. & Petrov, A.Y. Optimization of the Composition and Wet Granulation Technology of Drotaverine Hydrochloride Tablets. Pharm Chem J 39, 274–277 (2005). https://doi.org/10.1007/s11094-005-0131-y

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  • DOI: https://doi.org/10.1007/s11094-005-0131-y

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