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Optimization of nonlinear optical tweezers suitable to stretch DNA molecules without broken state

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Abstract

The positioning of the trapped bead and DNA’s stretching dynamics in the nonlinear optical tweezers are numerically simulated by finite difference method using general Langevin. From the performance of longitudinal position-pulling time curves of bead and evolution of forces controlled by average laser power, the trapping time, possible maximum stretched length, and laser intensity threshold of to broken DNA molecule are found. We also discussed the suitable conditions to avoid broken and overstretched states for longitudinally optical stretched DNA molecule. Finally, the optimized configuration of NOT for DNA molecules having different contour lengths is proposed.

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Acknowledgements

This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under Grant Number 103.03-2018.342.

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Authors and Affiliations

  1. Ho Chi Minh City University of Food Industry, 140 Le Trong Tan, Tan Phu, Ho Chi Minh City, Vietnam

    Quy Ho Quang & Thanh Thai Doan

  2. Academy of Military Science and Technology, 17 Hoang Sam, Hanoi, Vietnam

    Quy Ho Quang, Tuan Doan Quoc, Le Ly Nguyen & Thang Nguyen Manh

Authors
  1. Quy Ho Quang
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  2. Thanh Thai Doan
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  3. Tuan Doan Quoc
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  4. Le Ly Nguyen
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  5. Thang Nguyen Manh
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Correspondence to Thang Nguyen Manh.

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Ho Quang, Q., Thai Doan, T., Doan Quoc, T. et al. Optimization of nonlinear optical tweezers suitable to stretch DNA molecules without broken state. Opt Quant Electron 52, 189 (2020). https://doi.org/10.1007/s11082-020-02307-7

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