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Pathogenesis of Depression in Alzheimer’s Disease

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Abstract

Depression is a prevalent occurrence among Alzheimer’s disease (AD) patients, yet its underlying mechanism remains unclear. Recent investigations have revealed that several pathophysiological changes associated with Alzheimer’s disease can lead to mood disorders. These alterations include irregularities in monoamine neurotransmitters, disruptions in glutamatergic synaptic transmission, neuro-inflammation, dysfunction within the hypothalamic-pituitary-adrenocortical (HPA) axis, diminished levels of brain-derived neurotrophic factor (BDNF), and hippocampal atrophy. This review consolidates research findings from pertinent fields to elucidate the mechanisms underlying depression in Alzheimer’s disease, aiming to provide valuable insights for the study of its mechanisms and clinical treatment.

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Funding

This research was funded by the National Natural Science Foundation of China (No. 81873108), the Excellent Creative Talents Support Program of Heilongjiang University of Chinese Medicine (No. 2018RCQ08), the Research Foundation of Heilongjiang University of Chinese Medicine (No. 2019BJP02), and the Traditional Chinese Medicine Scientific Research Project in Heilongjiang Province (No. ZHY2022-118).

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  1. Qingyang Zhan and Fanyi Kong have contributed equally to this work.

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  1. Institute of Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin, 150040, China

    Qingyang Zhan, Fanyi Kong, Shuai Shao, Bo Zhang & Shuming Huang

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SMH and QYZ led the conception of the manuscript. QYZ, SMH, and FYK interpreted the relevant literature and drafted the manuscript. QYZ, SMH, FYK, BZ, and SS participated in the literature collection and interpretation. SMH and BZ made critical revisions to the manuscript with input from all authors. All authors reviewed the manuscript.

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Zhan, Q., Kong, F., Shao, S. et al. Pathogenesis of Depression in Alzheimer’s Disease. Neurochem Res 49, 548–556 (2024). https://doi.org/10.1007/s11064-023-04061-0

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