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Relationship of Sulfatides Physiological Function and Peroxisome Proliferator-Activated Receptor α

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Abstract

Sulfatides are unique sphingolipids present in the serum and the plasma membrane. Sulfatides exert important functions in a number of systems in the human body, including the nervous, immune, cardiovascular, and coagulation systems.Furthermore, it is closely related to tumor occurrence, development, and metastasis. Peroxisome proliferators-activated receptor α (PPARα) is a class of the nuclear receptor superfamily of transcription factors, which is a potential regulator of sulfatides. This review not only summarizes the current knowledge on the physiological functions of sulfatides in various systems, but also discusses the possible PPARα regulatory mechanisms in sulfatide metabolism and functions. The results of the present analysis provide deep insights and further novel ideas for expanding the research on the physiological function and clinical application of sulfatides.

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  1. Tong-tong Li and Gang Li have contribute equally to this work.

Authors and Affiliations

  1. General Clinical Laboratory, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China

    Tong-tong Li, Rui Hu, Xin Ji, Chang Liu & Yun-ting Shao

  2. Department of Geriatrics, Hebei General Hospital, Shijiazhuang, 050000, China

    Gang Li

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TL, GL and RH together wrote the first manuscript and are the major contributor in this paper. XJ, CL and YS substantively revised it. All authors have approved the submitted version.

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Correspondence to Rui Hu.

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Li, Tt., Li, G., Hu, R. et al. Relationship of Sulfatides Physiological Function and Peroxisome Proliferator-Activated Receptor α. Neurochem Res 48, 2059–2065 (2023). https://doi.org/10.1007/s11064-023-03895-y

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