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The Potential Crosstalk Between the Brain and Visceral Adipose Tissue in Alzheimer’s Development

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Abstract

The bidirectional communication between the brain and peripheral organs have been widely documented, but the impact of visceral adipose tissue (VAT) dysfunction and its relation to structural and functional brain changes have yet to be fully elucidated. This review initially examines the clinical evidence supporting associations between the brain and VAT before visiting the roles of the autonomic nervous system, fat and glucose metabolism, neuroinflammation, and metabolites. Finally, the possible effects and potential mechanisms of the brain-VAT axis on the pathogenesis of Alzheimer’s disease are discussed, providing new insights regarding future prevention and therapeutic strategies.

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Authors and Affiliations

  1. Faculty of Pharmacy, HUTECH University, Ho Chi Minh City, 700000, Vietnam

    Thuy Trang Nguyen

  2. Department of BioNano Technology, Gachon University, Seongnam, 461-701, Republic of Korea

    John Hulme

  3. Vietnam Sports Hospital, Ministry of Culture, Sports and Tourism, Hanoi, 100000, Vietnam

    Tuong Kha Vo

  4. Department of Sports Medicine, University of Medicine and Pharmacy (VNU-UMP), Vietnam National University Hanoi, Hanoi, 100000, Vietnam

    Tuong Kha Vo

  5. Department of Biomedical Engineering, School of Medicine, Vietnam National University Ho Chi Minh City (VNU-HCM), Ho Chi Minh City, 700000, Vietnam

    Giau Van Vo

  6. Research Center for Genetics and Reproductive Health (CGRH), School of Medicine, Vietnam National University Ho Chi Minh City (VNU-HCM), Ho Chi Minh City, 700000, Vietnam

    Giau Van Vo

  7. Vietnam National University Ho Chi Minh City (VNU-HCM), Ho Chi Minh City, 700000, Vietnam

    Giau Van Vo

Authors
  1. Thuy Trang Nguyen
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  2. John Hulme
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  3. Tuong Kha Vo
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  4. Giau Van Vo
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Contributions

TTN: Conceptualization, Data curation, Methodology, Writing—Original draft preparation, Visualization. JH: Conceptualization, Data curation, Methodology and Revision. TKV: Conceptualization, Methodology, Writing—Original draft preparation. GVV: Conceptualization, Methodology, Writing—Original draft preparation, Revision, and Visualization.

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Correspondence to John Hulme or Giau Van Vo.

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Nguyen, T.T., Hulme, J., Vo, T.K. et al. The Potential Crosstalk Between the Brain and Visceral Adipose Tissue in Alzheimer’s Development. Neurochem Res 47, 1503–1512 (2022). https://doi.org/10.1007/s11064-022-03569-1

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  • DOI: https://doi.org/10.1007/s11064-022-03569-1

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