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Concepts of Neuroendocrine Cardiology and Neuroendocrine Immunology, Chemistry and Biology of Signal Molecules

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Abstract

Discovery of neurosecretion of cardioactive neurohormones produced by hypothalamic nuclei (NSO and NPV), as well as the biosynthesis of several immunomodulators (signal molecules of the neuroendocrine immune system of brain), deciphering of their chemical structure and study of their biological properties led to the foundation of two important trends of neurobiology: neuroendocrine immunology and cardiology. Hormone formation by atrium ganglionary nerve cells and auriculum establishment of neurohumoral interactions between hypothalamic and atrium neurosecretion indicated the existence of the system neuroendocrine hypothalamus—endocrine heart. Study of their biological properties promoted creation of powerful neurohormonal preparations for the treatment of immune, cardio-vascular, neurodegenerative, infectious and tumor diseases. Concepts suggested by us on neuroendocrine cardiology and immunology, create large perspectives for development of the theory and its implementation in medicine.

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This paper is dedicated to Professor Abel Lajtha, present-day outstanding neurobiologist, neurochemist, fine personality and my great friend. Basic neurochemical studies carried out by Prof. A. Lajtha on proteolysis of brain proteins and peptides, on biosynthesis and metabolism of neurotransmitters proteins and peptides at pathological states of CNS and brain constitute golden fund in the Science of Brain. Neurochemical Center in New York headed by him became a real educational-training citadel for neurochemistry, and home for young scientists from different countries of the world. Neurochemical Research and Handbook of Neurochemistry and Molecular Neurobiology founded by Prof. A. Lajtha became an oasis for wide interdisciplinary researches of neurobiological problems. To our great pleasure Prof. A. Lajtha’s titanic activity on dissemination of modern achievements in neurochemistry and molecular biology continues. Let him be healthy to serve the progress of science.

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  1. H.Kh. Buniatian Institute of Biochemistry, NAS RA, 5/1 Sevak Str., Yerevan, 0014, Armenia

    Armen Galoyan

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  1. Armen Galoyan
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Correspondence to Armen Galoyan.

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Special Issue: In Honor of Dr. Abel Lajtha.

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Galoyan, A. Concepts of Neuroendocrine Cardiology and Neuroendocrine Immunology, Chemistry and Biology of Signal Molecules. Neurochem Res 35, 2001–2017 (2010). https://doi.org/10.1007/s11064-010-0306-0

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