Skip to main content
Log in

NMDA Receptors Mediate Consolidation of Contextual Memory in the Hippocampus after Context Preexposure

  • Published:
Neurochemical Research Aims and scope Submit manuscript

Abstract

Male Wistar rats received bilateral infusions of vehicle (VEH) or aminophosphonopentanoic acid (AP5), an N-metil-D-aspartate (NMDA) receptor antagonist, into the dorsal hippocampus immediately after inhibitory avoidance (IA) training. Intrahippocampal infusion of AP5 blocked 24 h IA retention. In the second experiment, animals were preexposed to the IA training context 24 h prior to training and received an infusion of either VEH or AP5 immediately after the preexposure trial and a second infusion of VEH or AP5 immediately after IA training. AP5 did not affect retention in animals preexposed to the IA box and given VEH after preexposure, but blocked retention when given after both preexposure and training. AP5 impaired retention in rats preexposed to an environment distinct from the IA box. These results suggest that NMDA receptors in the dorsal hippocampus mediate the formation of a contextual representation of the task environment.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. C. Rampon Y. P. Tang J. Goodhouse E. Shimizu M. Kyin J. Z. Tsien (2000) ArticleTitleEnrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice Nat. Neurosci. 3 238–244 Occurrence Handle10700255 Occurrence Handle1:CAS:528:DC%2BD3cXhs1Smu78%3D

    PubMed  CAS  Google Scholar 

  2. Y. P. Tang E. Shimizu G. R. Dube C. Rampon G. A. Kerchner M. Zhuo G. Liu J. Z. Tsien (1999) ArticleTitleGenetic enhancement of learning and memory in mice Nature 401 63–69 Occurrence Handle10485705 Occurrence Handle1:CAS:528:DyaK1MXlvVGms70%3D

    PubMed  CAS  Google Scholar 

  3. J. Z. Tsien P. T. Huerta S. Tonegawa (1996) ArticleTitleThe essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory Cell 87 1327–1338 Occurrence Handle8980238 Occurrence Handle1:CAS:528:DyaK2sXitlSjuw%3D%3D

    PubMed  CAS  Google Scholar 

  4. I. Izquierdo J. H. Medina (1997) ArticleTitleMemory formation: the sequence of biochemical events in the hippocampus and its connection to activity in other brain structures Neurobiol. Learn. Mem. 68 285–316 Occurrence Handle9398590 Occurrence Handle1:CAS:528:DyaK2sXnslOhsro%3D

    PubMed  CAS  Google Scholar 

  5. J. J. Kim J. P. DeCola J. Landeira-Fernandez M. S. Fanselow (1991) ArticleTitleN-methyl-D-aspartate receptor antagonist APV blocks acquisition but not expression of fear conditioning Behav. Neurosci. 105 126–133 Occurrence Handle10.1037/0735-7044.105.1.126 Occurrence Handle1673846 Occurrence Handle1:STN:280:By6B383kt1Q%3D

    Article  PubMed  CAS  Google Scholar 

  6. R. Roesler C. R. Kuyven A. V. S. Kruel J. Quevedo M. B. C. Ferreira (1998) ArticleTitleInvolvement of hippocampal NMDA receptors in retention of shuttle avoidance conditioning in rats Braz. J. Med. Biol. Res. 31 1601–1604 Occurrence Handle10.1590/S0100-879X1998001200014 Occurrence Handle9951558 Occurrence Handle1:CAS:528:DyaK1MXhsVymtw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  7. R. Roesler N. Schröder M. R. M. Vianna J. Quevedo E. Bromberg F. Kapczinski M. B. C. Ferreira (2003) ArticleTitleDifferential involvement of hippocampal and amygdalar NMDA receptors in contextual and aversive aspects of inhibitory avoidance memory in rats Brain Res. 975 207–213 Occurrence Handle10.1016/S0006-8993(03)02656-8 Occurrence Handle12763609 Occurrence Handle1:CAS:528:DC%2BD3sXjvV2ltro%3D

    Article  PubMed  CAS  Google Scholar 

  8. R. Roesler M. Vianna M. K. Sant’Anna C. R. Kuyven A. V. S. Kruel J. Quevedo M. B. C. Ferreira (1998) ArticleTitleIntrahippocampal infusion of the NMDA receptor antagonist AP5 impairs retention of an inhibitory avoidance task: protection from impairment by pretraining or preexposure to the task apparatus Neurobiol. Learn. Mem. 69 87–91 Occurrence Handle10.1006/nlme.1997.3810 Occurrence Handle9619989 Occurrence Handle1:CAS:528:DyaK1cXjsF2hsLs%3D

    Article  PubMed  CAS  Google Scholar 

  9. S. L. Young D. L. Bohenek M. S. Fanselow (1994) ArticleTitleNMDA processes mediate anterograde amnesia of contextual fear conditioning induced by hippocampal damage: immunization against amnesia by context preeposure Behav. Neurosci. 108 19–29 Occurrence Handle8192845 Occurrence Handle1:STN:280:ByuB2M%2Fjt1M%3D

    PubMed  CAS  Google Scholar 

  10. K. Nakazawa T. J. McHugh M. A. Wilson S. Tonegawa. (2004) ArticleTitleNMDA receptors, place cells and hippocampal spatial memory Nat. Rev. Neurosci. 5 361–372 Occurrence Handle10.1038/nrn1385 Occurrence Handle15100719 Occurrence Handle1:CAS:528:DC%2BD2cXjt1ClsLg%3D

    Article  PubMed  CAS  Google Scholar 

  11. G. Riedel B. Platt J. Micheau (2003) ArticleTitleGlutamate receptor function in learning and memory Behav. Brain Res. 140 1–47 Occurrence Handle10.1016/S0166-4328(02)00272-3 Occurrence Handle12644276 Occurrence Handle1:CAS:528:DC%2BD3sXitV2ht70%3D

    Article  PubMed  CAS  Google Scholar 

  12. D. M. Bannerman M. A. Good S. P. Butcher M. Ramsay R. G Morris (1995) ArticleTitleDistinct components of spatial learning revealed by prior training and NMDA receptor blockade Nature 378 182–186 Occurrence Handle10.1038/378182a0 Occurrence Handle7477320 Occurrence Handle1:CAS:528:DyaK2MXptlSmtLg%3D

    Article  PubMed  CAS  Google Scholar 

  13. D. Saucier D. P. Cain (1995) ArticleTitleSpatial learning without NMDA receptor-dependent long-term potentiation Nature 378 186–189 Occurrence Handle10.1038/378186a0 Occurrence Handle7477321 Occurrence Handle1:CAS:528:DyaK2MXptlSmtLk%3D

    Article  PubMed  CAS  Google Scholar 

  14. M. J. Sanders M. S. Fanselow (2003) ArticleTitlePre-training prevents context fear conditioning deficits produced by hippocampal NMDA receptor blockade Neurobiol. Learn. Mem. 80 123–129 Occurrence Handle10.1016/S1074-7427(03)00040-6 Occurrence Handle12932427 Occurrence Handle1:CAS:528:DC%2BD3sXmsVGrtb8%3D

    Article  PubMed  CAS  Google Scholar 

  15. C. Castellano V. Cestari A. Ciamei F. Pavone (1999) ArticleTitleMK-801-induced disruptions of one-trial inhibitory avoidance are potentiated by stress and reversed by naltrexone Neurobiol. Learn. Mem. 72 215–229 Occurrence Handle10.1006/nlme.1999.3908 Occurrence Handle10536099 Occurrence Handle1:CAS:528:DyaK1MXmvVejsLw%3D

    Article  PubMed  CAS  Google Scholar 

  16. G. Paxinos C Watson (1997) The Rat Brain in Sterotaxic Coordinates Academic Press San Diego

    Google Scholar 

  17. K. C. Liang (1999) ArticleTitlePre- or post-training injection of buspirone impaired retention in the inhibitory avoidance task: involvement of amygdala 5HT1A receptors Eur. J. Neurosci. 11 1491–1500 Occurrence Handle10.1046/j.1460-9568.1999.00561.x Occurrence Handle10215901 Occurrence Handle1:STN:280:DyaK1M3jtl2guw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  18. R. Roesler D. J. Berlau R. T. LaLumiere B. Roozendaal J. L. McGaugh (2001) ArticleTitleInhibitory avoidance requires contextual experience but not an instrumental response during training Soc. Neurosci. Abstr. 27 595

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Rafael Roesler.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Roesler, R., Reolon, G.K., Luft, T. et al. NMDA Receptors Mediate Consolidation of Contextual Memory in the Hippocampus after Context Preexposure. Neurochem Res 30, 1407–1411 (2005). https://doi.org/10.1007/s11064-005-8509-5

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11064-005-8509-5

Keywords

Navigation