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Transcranial magnetic stimulation for post-operative neurorehabilitation in neuro-oncology: a review of the literature and future directions

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A Correction to this article was published on 19 April 2022

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Abstract

Introduction

Transcranial magnetic stimulation (TMS) is a neuromodulation technology capable of targeted stimulation and inhibition of cortical areas. Repetitive TMS (rTMS) has demonstrated efficacy in the treatment of several neuropsychiatric disorders, and novel uses of rTMS for neurorehabilitation in patients with acute and chronic neurologic deficits are being investigated. However, studies to date have primarily focused on neurorehabilitation in stroke patients, with little data supporting its use for neurorehabilitation in brain tumor patients.

Methods

We performed a review of the current available literature regarding uses of rTMS for neurorehabilitation in post-operative neuro-oncologic patients.

Results

Data have demonstrated that rTMS is safe in the post-operative neuro-oncologic patient population, with minimal adverse effects and no documented seizures. The current evidence also demonstrates potential effectiveness in terms of neurorehabilitation of motor and language deficits.

Conclusions

Although data are overall limited, both safety and effectiveness have been demonstrated for the use of rTMS for neurorehabilitation in the neuro-oncologic population. More randomized controlled trials and specific comparisons of contralateral versus ipsilateral rTMS protocols should be explored. Further work may also focus on individualized, patient-specific TMS treatment protocols for optimal functional recovery.

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Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Funding

The authors declare that no funds, grants, or other support were received during the preparation of this manuscript.

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Authors and Affiliations

  1. Department of Neurological Surgery, Lenox Hill Hospital/Donald and Barbara Zucker School of Medicine at Hofstra, New York, NY, USA

    Evan H. Einstein, Hamza Khilji & Randy S. D’Amico

  2. Robert Wood Johnson School of Medicine, Rutgers University, New Brunswick, NJ, USA

    Nicholas B. Dadario

  3. Department of Neurology, Lenox Hill Hospital/Donald and Barbara Zucker School of Medicine at Hofstra, New York, NY, USA

    Justin W. Silverstein

  4. Neuro Protective Solutions, New York, NY, USA

    Justin W. Silverstein

  5. Centre for Minimally Invasive Neurosurgery, Prince of Wales Private Hospital, Sydney, NSW, Australia

    Michael E. Sughrue

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Contributions

All authors contributed to the preparation of this manuscript. Literature search and results collection were performed by EHE and HK. Primary writing of the body of the manuscript was performed by Evan Einstein and RSD. Several sections were written by NBD and MES. The figures were created by NBD and MES. All authors were involved in the editing and revision of this manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Evan H. Einstein.

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Conflict of interest

Dr. Michael Sughrue is the Chief Medical Officer, co-founder, and shareholder for Omniscient Neurotechnology. Figures 1 and 2 were made using software from Omniscient Neurotechnology.

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Einstein, E.H., Dadario, N.B., Khilji, H. et al. Transcranial magnetic stimulation for post-operative neurorehabilitation in neuro-oncology: a review of the literature and future directions. J Neurooncol 157, 435–443 (2022). https://doi.org/10.1007/s11060-022-03987-9

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  • DOI: https://doi.org/10.1007/s11060-022-03987-9

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