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Association of telomerase gene hTERT polymorphism and malignant gliomas

  • Lab. Investigation-HUman/Animal Tissue
  • Published:
Journal of Neuro-Oncology Aims and scope Submit manuscript

Abstract

Background

The MNS16A polymorphism is located in the downstream region of the hTERT gene and affects telomerase activity.

Methods

MNS16A has been investigated as a potential risk factor and/or prognostic marker for malignant glioma in a cohort of 352 patients (205 glioblastoma, 147 anaplastic gliomas) and 305 controls.

Results

The S (“short”) allele (which results in a higher telomerase activity) was significantly more frequent in glioma patients compared to the control population (278/704 = 39.5% vs. 200/610 = 32.8%; P = 0.012). The odd ratios were 1 for LL (taken as reference), 1.33 [0.96; 1.84] for SL and 2.05 [1.22; 3.44] for SS. However, in contrast to a previous report, no significant difference of survival was found between SS, LL and SL allelotypes.

Conclusion

We found here the short allele of MNS16A more frequent in glioma patients, but it did not seem to be predictive of survival.

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Acknowledgements

This work was supported by the grants from the Institut National du Cancer (PL 046), the Délégation à la Recherche Clinique (AP-HP; grant n° MUL 03012) and the Ligue Nationale contre le Cancer, comité d’Ile et Villaine. The authors gratefully thank Anne-Marie Lekieffre, Muriel Brandel, Marc Ouzounian and Tristan Salmon-Legagneur from the ARTC for their precious assistance.

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Authors and Affiliations

  1. INSERM, U711, Biologie des Interactions Neurones & Glie, Université Pierre et Marie Curie, Faculté de Médecine, Paris 13, France

    Catherine Carpentier, Florent Gros, Sibille Everhard, Yannick Marie, Khe Hoang-Xuan, Jean-Yves Delattre & Marc Sanson

  2. Service de Neurologie Mazarin, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, 75651, Paris Cedex 13, France

    Julie Lejeune, Gentian Kaloshi, Florence Laigle-Donadey, Khe Hoang-Xuan, Jean-Yves Delattre & Marc Sanson

  3. Service de Neurologie Mazarin, Groupe Hospitalier Pitié-Salpêtrière, 47 boulevard de l’Hôpital, 75013, Paris, France

    Marc Sanson

Authors
  1. Catherine Carpentier
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  2. Julie Lejeune
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  3. Florent Gros
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  4. Sibille Everhard
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  5. Yannick Marie
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  6. Gentian Kaloshi
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  7. Florence Laigle-Donadey
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  8. Khe Hoang-Xuan
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  9. Jean-Yves Delattre
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  10. Marc Sanson
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Corresponding author

Correspondence to Marc Sanson.

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Carpentier, C., Lejeune, J., Gros, F. et al. Association of telomerase gene hTERT polymorphism and malignant gliomas. J Neurooncol 84, 249–253 (2007). https://doi.org/10.1007/s11060-007-9378-3

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  • DOI: https://doi.org/10.1007/s11060-007-9378-3

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