Summary
The authors have reviewed the results, the indications and the controversies regarding radiotherapy and chemotherapy of patients with newly diagnosed and recurrent brain metastases. Whole-brain radiotherapy, radiosurgery, hypofractionated stereotactic radiotherapy, brachytherapy and chemotherapy are the available options. New radiosensitizers and cytotoxic or cytostatic agents are being investigated. Adjuvant whole brain radiotherapy, either after surgery or radiosurgery, and prophylactic cranial irradiation in small-cell lung cancer are discussed, taking into account local control, survival, and risk of late neurotoxicity. Increasingly, the different treatments are tailored to the different prognostic subgroups, as defined by Radiation Therapy Oncology Group RPA Classes.
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References
M Diener-West TW Dobbins TL Phillips DF Nelson (1989) ArticleTitleIdentification of an optimal subgroup for treatment evaluation of patients with brain metastases using RTOG Study 7916 Int J Radiat Oncol Biol Phys 16 669–673 Occurrence Handle2646260
L Gaspar C Scott M Rotman S Asbell T Phillips T Wasserman WG McKenna R Byhardt (1997) ArticleTitleRecursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials Int J Radiat Oncol Biol Phys 37 745–751 Occurrence Handle10.1016/S0360-3016(96)00619-0 Occurrence Handle9128946
FJ Lagerwaard PC Levendag PJ Nowak WM Eijkenboom PE Hanssens PI Schmitz (1999) ArticleTitleIdentification of prognostic factors in patients with brain metastases: a review of 1292 patients Int J Radiat Oncol Biol Phys 43 795–803 Occurrence Handle10.1016/S0360-3016(98)00442-8 Occurrence Handle10098435
MA Chidel JH Suh CA Reddy ST Chao MF Lundbeck GH Barnett (2000) ArticleTitleApplication of recursive partitioning analysis and evaluation of the use of whole-brain radiation among patients treated with stereotactic radiosurgery for newly diagnosed brain metastases Int J Radiat Oncol Biol Phys 47 993–999 Occurrence Handle10.1016/S0360-3016(00)00527-7 Occurrence Handle10863070
L Gaspar C Scott K Murray W Curran (2000) ArticleTitleValidation of the RTOG recursive partitioning analysis (RPA) classification for brain metastases Int J Radiat Oncol Biol Phys 47 1001–1006 Occurrence Handle10.1016/S0360-3016(00)00547-2 Occurrence Handle10863071
C Nieder U Nestle B Motaref K Walter M Niewald K Schnabel (2000) ArticleTitlePrognostic factors in brain metastases: should patients be selected for aggressive treatment according to recursive partitioning analysis (RPA) classes Int J Radiat Oncol Biol Phys 46 297–302 Occurrence Handle10.1016/S0360-3016(99)00416-2 Occurrence Handle10661335
E Weltman JV Salvajoli RA Brandt R Morais Hanriot Particlede FE Prisco JC Cruz R Oliveira Borges Particlede M Lagatta D Ballas Wajsbrot (2001) ArticleTitleRadiosurgery for brain metastases: who may not benefit Int J Radiat Oncol Biol Phys 51 1320–1327 Occurrence Handle10.1016/S0360-3016(01)01696-0 Occurrence Handle11728693
KJ Murray C Scott B Zachariah JM Michalski W Demas NL Vora A Whitton B Movsas (2000) ArticleTitleImportance of the Mini-Mental Status Examination in the treatment of patients with brain metastases: a report from the Radiation Therapy Oncology Group protocol Int J Radiat Oncol Biol Phys 48 59–64 Occurrence Handle10.1016/S0360-3016(00)00600-3 Occurrence Handle10924972
S Maesawa D Kondziolka TP Thompson JC Flickinger L Dade (2000) ArticleTitleBrain metastases in patients with no known primary tumor The role of stereotactic radiosurgery. Cancer 89 1095–1101
LN Nguyen MH Maor MJ Oswald (1998) ArticleTitleBrain metastases as the only manifestation of an undetected primary tumor Cancer 83 2181–2184 Occurrence Handle10.1002/(SICI)1097-0142(19981115)83:10<2181::AID-CNCR17>3.0.CO;2-J Occurrence Handle9827723
R Rudà M Borgognone F Benech E Vasario R Soffietti (2001) ArticleTitleBrain metastases from unknown primary tumor A prospective study. J Neurol 248 394–398
S Bartelt J Lutterbach (2003) ArticleTitleBrain metastases in patients with cancer of unknown primary J Neurooncol 64 249–253 Occurrence Handle10.1023/A:1025621819250 Occurrence Handle14558600
DR Macdonald T Cascino SC Schold JG Cairncross (1990) ArticleTitleResponse criteria for Phase II studies of malignant glioma J Clin Oncol 8 1277–1280 Occurrence Handle2358840
WF Regine C Scott K Murray W Curran (2001) ArticleTitleNeurocognitive outcome in brain metastases patients treated with accelerated-fractionation vs accelerated-hyperfractionated radiotherapy: an analysis from Radiation Therapy Oncology Group study 91–04 Int J Radiat Oncol Biol Phys 51 711–717 Occurrence Handle10.1016/S0360-3016(01)01676-5 Occurrence Handle11597813
MP Mehta WR Shapiro MJ Glantz RA Patchell MA Weitzner CA Meyers CJ Schultz WH Roa M Leibenhaut J Ford W Curran S Phan JA Smith RA Miller MF Renschler (2002) ArticleTitleLead-in phase to randomized trial of motexafin gadolinium and whole-brain radiation for patients with brain metastases: centralized assessment of magnetic resonance imaging, neurocognitive, and neurologic end points J Clin Oncol 20 3445–3453 Occurrence Handle10.1200/JCO.2002.07.500 Occurrence Handle12177105
S Zimm GL Wampler D Stablein T Hazra HF Young (1981) ArticleTitleIntracerebral metastases in solid-tumor patients: natural history and results of treatment Cancer 48 384–394 Occurrence Handle7237407
Posner JB: Brain metastases. In: Posner JB (ed) Neurologic Complications of Cancer. FA Davis Co, Philadelphia, pp 78–95.
JG Cairncross NL Chernik JH Kim JB Posner (1979) ArticleTitleSterilization of cerebral metastases by radiation therapy Neurology 29 1195–1202 Occurrence Handle225696
BB Borgelt RD Gelber S Kramer LW Brady CH Chang LW Davis CA Perez FR Hendrickson (1980) ArticleTitleThe palliation of brain metastases: final results of the first two studies by the Radiation Therapy Oncology Group Int J Radiat Oncol Biol Phys 6 1–9 Occurrence Handle6154024
PJ Hoskin M Brada (2001) ArticleTitleRadiotherapy for brain metastases Clin Oncol 13 91–94
A Bezjak J Adam R Barton T Panzarella N Laperriere CS Wong W Mason C Buckley W Levin M McLean JSY Wu M Sia P Kirkbride (2002) ArticleTitleSymptom response after palliative radiotherapy for patients with brain metastases Eur J Cancer 38 487–496 Occurrence Handle10.1016/S0959-8049(01)00150-2 Occurrence Handle11872340
JM Kurtz R Gelber LW Brady RJ Carella JS Cooper (1981) ArticleTitleThe palliation of brain metastases in a favorable patient population: a randomized clinical trial by the Radiation Therapy Oncology Group Int J Radiat Oncol Biol Phys 7 891–895 Occurrence Handle6171553
B Borgelt R Gelber M Larson F Hendrickson T Griffin R Roth (1981) ArticleTitleUltra-rapid high dose irradiation schedules for the palliation of brain metastases: final results of the first two studies by the Radiation Therapy Oncology Group Int J Radiat Oncol Biol Phys 7 1633–1638 Occurrence Handle6174490
KJ Murray C Scott H Greenberg B Emami M Seider NL Vora C Olson A Whitton B Movsas W Curran (1997) ArticleTitleA randomized phase III study of accelerated hyperfractionated versus standard radiation in patients with unresected brain metastases: a report of the Radiation Therapy Oncology Group (RTOG) 9104 Int J Radiat Oncol Biol Phys 39 571–574 Occurrence Handle10.1016/S0360-3016(97)00341-6 Occurrence Handle9336134
PJ Hoskins J Crow HT Ford (1990) ArticleTitleThe influence of extent and local management on the outcome of radiotherapy for brain metastases Int J Radiat Oncol Biol Phys 19 111–115 Occurrence Handle2116386
HJ Eyre JD Ohlsen J Frank AF LoBuglio JD McCracken TJ Weatherall CM Mansfield (1984) ArticleTitleRandomized trial of radiotherapy versus radiotherapy plus metronidazole for the treatment metastatic cancer to brain. A Southwest Oncology Group study . J Neurooncol 2 325–330 Occurrence Handle10.1007/BF00178115 Occurrence Handle6397578
LM Angelis ParticleDe VE Currie JH Kim G Krol MA O'Hehir FM Farag CW Young JB Posner (1989) ArticleTitleThe combined use of radiation therapy and lonidamine in the treatment of brain metastases J Neurooncol 7 241–247 Occurrence Handle2677257
LT Komarnicky TL Phillips K Martz S Asbell S Isaacson R Urtasun (1991) ArticleTitleA randomized phase III protocol for the evaluation of misonidazole combined with radiation in the treatment of patients with brain metastases (RTOG-7916) Int J Radiat Oncol Biol Phys 20 53–58 Occurrence Handle1993631
TL Phillips CB Scott SA Leibel M Rotman IJ Weigensberg (1995) ArticleTitleResults of a randomized comparison of radiotherapy and bromodeoxyuridine with radiotherapy alone for brain metastases: report of RTOG trial 89–05 Int J Radiat Oncol Biol Phys 33 339–348 Occurrence Handle10.1016/0360-3016(95)00168-X Occurrence Handle7673021
P Carde R Timmerman MP Mehta CD Koprowski J Ford RB Tishler D Miles RA Miller MF Renschler (2001) ArticleTitleMulticenter phase Ib/II trial of the radiation enhancer motefaxin gadolinium in patients with brain metastases J Clin Oncol 19 2074–2083 Occurrence Handle11283141
MP Mehta P Rodrigus CH Terhaard A Rao J Suh W Roa L Souhami A Bezjak M Leibenhaut R Komaki C Schultz R Timmerman W Curran J Smith SC Phan RA Miller MF Renschler (2003) ArticleTitleSurvival and neurologic outcomes in a randomized trial of motexafin gadolinium and whole-brain radiation therapy in brain metastases J Clin Oncol 21 2529–2536 Occurrence Handle10.1200/JCO.2003.12.122 Occurrence Handle12829672
E Shaw C Scott J Suh S Kadish B Stea J Hackman A Pearlman K Murray L Gaspar M Mehta W Curran M Gerber (2003) ArticleTitleRSR13 plus cranial radiation therapy in patients with brain metastases: comparison with the Radiation Therapy Oncology Group Recursive Partitioning Analysis Brain Metastases Database J Clin Oncol 21 2364–2371 Occurrence Handle10.1200/JCO.2003.08.116 Occurrence Handle12805339
MB Hazuka JJ Kinzie (1988) ArticleTitleBrain metastases: results and effects of re-irradiation Int J Radiat Oncol Biol Phys 15 433–437 Occurrence Handle10.1016/S0360-3016(98)90026-8 Occurrence Handle2841266
WW Wong SE Schild TE Sawyer EG Shaw (1996) ArticleTitleAnalysis of outcome in patients reirradiated for brain metastases Int J Radiat Oncol Biol Phys 34 585–590 Occurrence Handle10.1016/0360-3016(95)02156-6 Occurrence Handle8621282
LM Angelis ParticleDe JY Delattre JB Posner (1989) ArticleTitleRadiation-induced dementia in patients cured of brain metastases Neurology 39 789–796 Occurrence Handle2725874
C Nieder K Schwerdtfeger WI Steudel K Schnabel (1998) ArticleTitlePatterns of relapse and late toxicity after resection and whole-brain radiotherapy for solitary brain metastases Strahlenther Onkol 174 275–278 Occurrence Handle9614957
EM Noordijk CJ Vecht H Haaxma-Reiche GW Padberg JH Voormolen FH Hoekstra JT Tans N Lambooij JA Metsaars AR Wattendorff (1994) ArticleTitleThe choice of treatment of single brain metastasis should be based on extracranial tumor activity and age Int J Radiat Oncol Biol Phys 29 711–717 Occurrence Handle8040016
JR Adler RS Cox I Kaplan DP Martin (1992) ArticleTitleStereotactic radiosurgical treatment of brain metastases J Neurosurg 76 444–449 Occurrence Handle1738025
MP Mehta JM Rozenthal B Levin TR Mackie SS Kubsad MA Gehring TJ Kinsella (1992) ArticleTitleDefining the role of radiosurgery in the management of brain metastases Int J Radiat Oncol Biol Phys 24 619–625 Occurrence Handle1429083
RB Engenhardt N Kimmig KH Hover B Wowra J Romahn WJ Lorenz G Kaick Particlevan M Wannenmacher (1993) ArticleTitleLong-term follow-up for brain metastases treated by percutaneous single high dose irradiation Cancer 71 1353–1361 Occurrence Handle8435811
JC Flickinger D Kondziolka LD Lunsford RJ Coffey ML Goodman EG Shaw WR Hudgins R Weiner GR IV Harsh PK Sneed (1994) ArticleTitleA multi-institutional experience with stereotactic radiosurgery for solitary brain metastasis Int J Radiat Oncol Biol Phys 28 797–802 Occurrence Handle8138431
E Alexander TM Moriarty RB Davis PY Wen HA Fine PM Black HM Kooy JS Loeffler (1995) ArticleTitleStereotactic radiosurgery for the definitive, noninvasive treatment of brain metastases J Natl Cancer Inst 87 34–40 Occurrence Handle7666461
RM Auchter JP Lamond E Alexander JM Buatti R Chappell WA Friedman TJ Kinsella AB Levin WR Noyes CJ Schultz JS Loeffler MP Mehta (1996) ArticleTitleA multi-institutional outcome and prognostic factor analysis of radiosurgery for resectable single brain metastasis Int J Radiat Oncol Biol Phys 35 27–35 Occurrence Handle10.1016/S0360-3016(96)85008-5 Occurrence Handle8641923
CY Shiau PK Sneed HK Shu KR Lamborn MW McDermott S Chang P Nowak PL Petti V Smith LJ Verhey M Ho E Park WM Wara PH Gutin DA Larson (1997) ArticleTitleRadiosurgery for brain metastases: relationship of dose and pattern of enhancement to local control Int J Radiat Oncol Biol Phys 37 375–383 Occurrence Handle10.1016/S0360-3016(96)00497-X Occurrence Handle9069310
MH Maor P Dubey SL Tucker AS Shiu BN Mathur R Sawaya FF Lang SJ Hassenbusch (2000) ArticleTitleStereotactic radiosurgery for brain metastases: results and prognostic factors Int J Cancer 90 157–162 Occurrence Handle10.1002/1097-0215(20000620)90:3<157::AID-IJC6>3.0.CO;2-I Occurrence Handle10900428
J Joseph JR Adler RS Cox SL Hancock (1996) ArticleTitleLinear accelerator-based stereotaxic radiosurgery for brain metastases: the influence of number of lesions on survival J Clin Oncol 14 1085–1092 Occurrence Handle8648361
KH Cho WA Hall BJ Gerbi PD Higgins M Bohen HB Clark (1998) ArticleTitlePatient selection criteria for the treatment of brain metastases with stereotactic radiosurgery J Neurooncol 40 73–86 Occurrence Handle10.1023/A:1006169109920 Occurrence Handle9874189
PK Sneed KR Lamborn JM orstner MW McDermott S Chang E Park PH Gutin TL Phillips WM Wara D Larson (1999) ArticleTitleRadiosurgery for brain metastases: is whole brain radiotherapy necessary Int J Radiat Oncol Biol Phys 3 549–558 Occurrence Handle10.1016/S0360-3016(98)00447-7
D Kondziolka A Patel LD Lunsford A Kassam JC Flickinger (1999) ArticleTitleStereotactic radiosurgery plus whole-brain radiotherapy versus radiotherapy alone for patients with multiple brain metastases Int J Radiat Oncol Biol Phys 45 427–434 Occurrence Handle10.1016/S0360-3016(99)00198-4 Occurrence Handle10487566
M Yamamoto M Ide S Nishio Y Urakawa (2002) ArticleTitleGamma knife radiosurgery for numerous brain metastases: is this a safe treatment Int J Radiat Oncol Biol Phys 53 1279–1283 Occurrence Handle10.1016/S0360-3016(02)02855-9 Occurrence Handle12128130
L Kihlstrom B Karlsson C Lindquist (1993) ArticleTitleGamma knife surgery for cerebral metastases. Implications for survival based on 16 years experience Stereotact Funct Neurosurg 61 (Suppl 1) 45–50
A Pirzkall J Debus F Lohr M Fuss B Rhein R Engenhart-Cabillic M Wannenmacher (1998) ArticleTitleRadiosurgery alone or in combination with whole-brain radiotherapy for brain metastases J Clin Oncol 16 3563–3569 Occurrence Handle9817276
Y Mori D Kondziolka JC Flickinger JM Kirkwood S Agarwala LD Lunsford (1998) ArticleTitleStereotactic radiosurgery for cerebral metastatic melanoma: factors affecting local disease control and survival Int J Radiat Oncol Biol Phys 42 581–589 Occurrence Handle10.1016/S0360-3016(98)00272-7 Occurrence Handle9806518
AM Peterson CC Meltzer EJ Evanson JC Flickinger D Kondziolka (1999) ArticleTitleMR imaging response of brain metastases after gamma knife stereotactic radiosurgery Radiology 211 807–814 Occurrence Handle10352610
G Noel JM Simon CA Valery P Cornu G Boisserie D Hasboun D Ledu B Tep JY Delattre C Marsault F Baillet JJ Mazeron (2003) ArticleTitleRadiosurgery for brain metastasis: impact of CTV on local control Radiother Oncol 68 15–21 Occurrence Handle10.1016/S0167-8140(03)00207-X Occurrence Handle12885447
SD Levine Z Petrovich AA Cohen-Gadol LS Masri DL Morton SJ O'Day R Essner V Zelman C Yu G Luxton ML Apuzzo (1999) ArticleTitleGamma knife radiosurgery for metastatic melanoma: an analysis of survival, outcome, and complications Neurosurgery 44 59–64 Occurrence Handle10.1097/00006123-199901000-00031 Occurrence Handle9894964
C Yu JC Chen ML Apuzzo S O'Day SL Giannotta JS Weber Z Petrovich (2002) ArticleTitleMetastatic melanoma to the brain: prognostic factors after gamma knife radiosurgery Int J Radiat Oncol Biol Phys 52 1277–1287 Occurrence Handle10.1016/S0360-3016(01)02772-9 Occurrence Handle11955740
A Schoeggl K Kitz M Reddy C Zauner (2002) ArticleTitleStereotactic radiosurgery for brain metastases from colorectal cancer Int J Colorectal Dis 17 150–155 Occurrence Handle10.1007/s00384-001-0362-7 Occurrence Handle12049308
JP Sheehan MH Sun D Kondziolka J Flickinger LD Lunsford (2003) ArticleTitleRadiosurgery in patients with renal cell carcinoma metastasis to the brain: long-term outcomes and prognostic factors influencing survival and local tumor control J Neurosurg 98 342–349 Occurrence Handle12593621
CF Huang D Kondziolka JC Flickinger LD Lunsford (1999) ArticleTitleStereotactic radiosurgery for brainstem metastases J Neurosurg 84 563–568
JM Buatti WA Friedman SL Meeks FJ Bova (2000) ArticleTitleRTOG 90–05: the real conclusion Int J Radiat Oncol Biol Phys 47 269–271 Occurrence Handle10.1016/S0360-3016(99)00506-4 Occurrence Handle10802348
PE Huber H Hawighorst M Fuss G Kaick Particlevan MF Wannenmacher J Debus (2001) ArticleTitleTransient enlargement of contrast uptake on MRI after linear accelerator (LINAC) stereotactic radiosurgery for brain metastases Int J Radiat Oncol Biol Phys 49 1339–1349 Occurrence Handle10.1016/S0360-3016(00)01511-X Occurrence Handle11286842
SN Sanghavi SS Miranpuri R Chappell JM Buatti PK Sneed JH Suh WF Regine E Weltman VJ King SJ Goetsch JC Breneman PW Sperduto C Scott S Mabanta MP Mehta (2001) ArticleTitleRadiosurgery for patients with brain metastases: a multi-institutional analysis, stratified by the RTOG recursive partitioning analysis method Int J Radiat Oncol Biol Phys 51 426–434 Occurrence Handle10.1016/S0360-3016(01)01622-4 Occurrence Handle11567817
PB Chougule M Burton-Williams S Saris (2000) ArticleTitleRandomized treatment of brain metastases with gamma knife radiosurgery, whole-brain radiotherapy or both. Int J Radiat Oncol Biol Phys 48(Suppl) 114 Occurrence Handle10.1016/S0360-3016(00)80024-3
PW Sperduto C Scott D Andrews (2000) ArticleTitlePreliminary report of RTOG 9508: a phase III trial comparing whole-brain irradiation alone versus whole-brain irradiation plus stereotactic radiosurgery for patients with two or three unresected brain metastases. Int J Radiat Oncol Biol Phys 48(Suppl) 113 Occurrence Handle10.1016/S0360-3016(00)80023-1
A Muacevic FW Kreth GA Horstmann R Schmid-Elsaesser B Wowra HJ Steiger HJ Reulen (1999) ArticleTitleSurgery and radiotherapy compared with gamma knife radiosurgery in the treatment of solitary cerebral metastases of small diameter J Neurosurg 91 35–43 Occurrence Handle10389878
BP O'Neill NJ Iturria MJ Link BE Pollock KV Ballman JR O'Fallon (2003) ArticleTitleA comparison of surgical resection and stereotactic radiosurgery in the treatment of solitary brain metastases Int J Radiat Oncol Biol Phys 55 1169–1176 Occurrence Handle10.1016/S0360-3016(02)04379-1 Occurrence Handle12654423
AK Bindal RK Bindal KR Hess A Shiu SJ Hassenbusch WM Shi R Sawaya (1996) ArticleTitleSurgery versus radiosurgery in the treatment of brain metastasis J Neurosurg 84 748–754 Occurrence Handle8622147
JS Loeffler HM Kooy PY Wen HA Fine CW Cheng EG Mannarino JS Tsai E Alexander (1990) ArticleTitleThe treatment of recurrent brain metastases with stereotactic radiosurgery J Clin Oncol 8 576–582 Occurrence Handle2179476
JCT Chen Z Petrovich SL Giannotta C Yu ML Apuzzo (2000) ArticleTitleRadiosurgical salvage therapy for patients presenting with recurrence of metastatic disease to the brain Neurosurgery 46 860–867 Occurrence Handle10.1097/00006123-200004000-00017 Occurrence Handle10764259
E Shaw C Scott L Souhami R Dinapoli R Kline J Loeffler N Farnan (2000) ArticleTitleSingle dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: final report of RTOG protocol 90–05 Int J Radiat Oncol Biol Phys 47 291–298 Occurrence Handle10.1016/S0360-3016(99)00507-6 Occurrence Handle10802351
MR McKenzie L Souhami JL Caron A Olivier JG Villemure EB Podgorsak (1993) ArticleTitleEarly and late complications following dynamic stereotactic radiosurgery and fractionated stereotactic radiotherapy Can J Neurol Sci 20 279–285 Occurrence Handle8313243
DY Gelblum H Lee M Bilsky C Pinola S Longford K Wallner (1998) ArticleTitleRadiographic findings and morbidity in patients treated with stereotactic radiosurgery Int J Radiat Oncol Biol Phys 42 391–395 Occurrence Handle10.1016/S0360-3016(98)00230-2 Occurrence Handle9788421
ST Chao JH Suh S Raja SY Lee G Barnett (2001) ArticleTitleThe sensitivity and specificity of FDG PET in distinguishing recurrent brain tumor from radionecrosis in patients treated with stereotactic radiosurgery Int J Cancer 96 191–197 Occurrence Handle10.1002/ijc.1016 Occurrence Handle11410888
MJ Rutigliano LD Lunsford D Kondziolka MJ Strauss V Khanna M Green (1995) ArticleTitleThe cost effectiveness of stereotactic radiosurgery versus surgical resection in the treatment of solitary matastatic brain tumors Neurosurgery 37 445–455 Occurrence Handle7501109
M Mehta W Noyes B Craig J Lamond R Auchter M French M Johnson A Levin B Badie I Robbins T Kinsella (1997) ArticleTitleA cost-effectiveness and cost-utility analysis of radiosurgery vs resection for single-brain metastases. Int J Radiat Oncol Biol Phys 39 445–454 Occurrence Handle10.1016/S0360-3016(97)00071-0
RW Laing AP Warrington F Hines JD Graham M Brada (1993) ArticleTitleFractionated stereotactic external beam radiotherapy in the management of brain metastases Eur J Cancer 29 1387–1391 Occurrence Handle10.1016/0959-8049(93)90007-3
MA Manning RM Cardinale SH Benedict BD Kavanagh RD Zwicker C Amir WC Broaddus (2000) ArticleTitleHypofractionated stereotactic radiotherapy as an alternative to radiosurgery for the treatment of patients with brain metastases Int J Radiat Oncol Biol Phys 47 603–608 Occurrence Handle10.1016/S0360-3016(00)00475-2 Occurrence Handle10837942
H Aoyama H Shirato R Onimaru K Kagei J Ikeda N Ishii Y Sawamura K Miyasaka (2003) ArticleTitleHypofractionated stereotactic radiotherapy alone without whole-brain irradiation for patients with solitary and oligo brain metastasis using noninvasive fixation of the skull Int J Radiat Oncol Biol Phys 56 793–800 Occurrence Handle10.1016/S0360-3016(03)00014-2 Occurrence Handle12788187
M Bernstein A Cabantog N Laperriere P Leung C Thomason (1995) ArticleTitleBrachytherapy for recurrent single brain metastasis Can J Neurol Sci 22 13–16 Occurrence Handle7750066
MW McDermott GR Cosgrove DA Larson PK Sneed PH Gutin (1996) ArticleTitleInterstitial brachytherapy for intracranial metastases Neurosurg Clin North Am 7 485–495
JA Bogart C Ungureanu E Shihadeh TC Chung GA King S Ryu C Kent JA Winfield (1999) ArticleTitleResection and permanent I-125 brachytherapy without whole brain irradiation for solitary brain metastasis from non-small cell lung carcinoma J Neurooncol 44 53–57 Occurrence Handle10.1023/A:1006285304892 Occurrence Handle10582669
JP Rock E Shaw A Sills M Vogelbaum M Ewend LR Rogers (2003) ArticleTitleInitial results of a phase 2 trial of resection and gliasite brachytherapy for a single brain metastasis Neuro-Oncology 5 IssueID4 345
A Mintz JG Cairncross (1998) ArticleTitleTreatment of a single brain metastasis The role of radiation following surgical resection. JAMA 280 1527–1529
SR Smalley MF Schray ER Laws ParticleJr JR O'Fallon (1987) ArticleTitleAdjuvant radiation therapy after surgical resection of solitary brain metastasis: association with pattern of failure and survival Int J Radiat Oncol Biol Phys 13 1611–1616 Occurrence Handle3117742
LM Angelis ParticleDe LR Mandell HT Thaler DW Kimmel JH Galicich Z Fuks JB Posner (1989) ArticleTitleThe role of postoperative radiotherapy after resection of single brain metastases Neurosurgery 24 798–805 Occurrence Handle2473409
RA Patchell PA Tibbs WF Regine RJ Dempsey M Mohiuddin RJ Kryscio WR Markesbery KA Foon B Young (1998) ArticleTitlePostoperative radiotherapy in the treatment of single metastases to the brain JAMA 280 1485–1489 Occurrence Handle10.1001/jama.280.17.1485 Occurrence Handle9809728
BG Fuller ID Kaplan J Adler RS Cox MA Bagshaw (1992) ArticleTitleStereotactic radiosurgery for brain metastases: the importance of adjuvant whole-brain irradiation Int J Radiat Oncol Biol Phys 23 413–418 Occurrence Handle1375218
H Shirato A Takamura M Tomita K Suzuki T Nishioka T Isu T Kato Y Sawamura K Miyamachi H Abe K Miyasaka (1997) ArticleTitleStereotactic irradiation without whole-brain irradiation for single brain metastasis Int J Radiat Oncol Biol Phys 37 385–391 Occurrence Handle10.1016/S0360-3016(96)00488-9 Occurrence Handle9069311
B Li J Yu M Suntharalingam AS Kennedy PP Amin Z Chen R Yin S Guo T Han Y Wang N Yu G Song L Wang (2000) ArticleTitleComparison of three treatment options for single brain metastasis from lung cancer Int J Cancer 90 37–45 Occurrence Handle10.1002/(SICI)1097-0215(20000220)90:1<37::AID-IJC5>3.3.CO;2-Z Occurrence Handle10725856
T Hasegawa D Kondziolka JC Flickinger A Germanwala LD Lunsford (2003) ArticleTitleBrain metastases treated with radiosurgery alone: an alternative to whole-brain radiotherapy Neurosurgery 52 1318–1326 Occurrence Handle10.1227/01.NEU.0000064569.18914.DE Occurrence Handle12762877
WF Regine JL Huhn RA Patchell WH St Clair J Strottmann A Meigooni M Sanders AB Young (2002) ArticleTitleRisk of symptomatic brain tumor recurrence and neurologic deficit after radiosurgery alone in patients with newly diagnosed brain metastases: results and implications Int J Radiat Oncol Biol Phys 52 333–338 Occurrence Handle10.1016/S0360-3016(01)02645-1 Occurrence Handle11872278
J Lutterbach D Cyron K Henne CB Ostertag (2003) ArticleTitleRadiosurgery followed by planned observation in patients with one to three brain metastases Neurosurgery 52 1066–1074 Occurrence Handle10.1227/01.NEU.0000057695.46198.FE Occurrence Handle12699548
HR Withers R Suwinski (1998) ArticleTitleRadiation dose response for subclinical metastases Semin Radiat Oncol 8 224–228 Occurrence Handle9634499
LH Einhorn (1995) ArticleTitleThe case against prophylactic cranial irradiation in limited small cell lung cancer Semin Radiat Oncol 5 57–60 Occurrence Handle10717127
EF Vines C Pechoux ParticleLe R Arriagada (2003) ArticleTitleProphylactic cranial irradiation in small-cell lung cancer Semin Oncol 30 38–46 Occurrence Handle10.1053/sonc.2003.50013
A Auperin R Arriagada JP Pignon C Pechoux ParticleLe A Gregor RJ Stephens PE Kristjansen BE Johnson H Ueoka H Wagner J Aisner (1999) ArticleTitleProphylactic cranial irradiation for patients with small-cell lung cancer in complete remission. Prophylactic Cranial Irradiation Overview Collaborative Group . N Engl J Med 341 476–484 Occurrence Handle10.1056/NEJM199908123410703 Occurrence Handle10441603
AP Meert M Paesmans T Berghmans B Martin C Mascaux F Vallot JM Verdebout JJ Lafitte JP Sculier (2001) ArticleTitleProphylactic cranial irradiation in small-cell lung cancer: a systematic review of the literature with meta-analysis BMC Cancer 1 5 Occurrence Handle10.1186/1471-2407-1-5 Occurrence Handle11432756
TJ Robnett M Machtay JP Stevenson KM Algazy SM Hahn (2001) ArticleTitleFactors affecting the risk of brain metastases after definitive chemoradiation for locally advanced non-small-cell lung carcinoma J Clin Oncol 19 1344–1349 Occurrence Handle11230477
GJ Lesser (1996) ArticleTitleChemotherapy of cerebral metastases from solid tumors Neurosurgery Clin North Am 7 527–536
PE Postmus EF Smit (1999) ArticleTitleChemotherapy for brain metastases of lung cancer: a review Ann Oncol 10 753–759 Occurrence Handle10.1023/A:1008318515795 Occurrence Handle10470420
CA Kristensen PE Kristjansen HH Hansen (1992) ArticleTitleSystemic chemotherapy of brain metastases from SCLC: a review J Clin Oncol 10 1498–1502 Occurrence Handle1325541
F Grossi T Scolaro L Tixi M Loprevite A Ardizzoni (2001) ArticleTitleThe role of systemic chemotherapy in the treatment of brain metastases from small-cell lung cancer Crit Rev Oncol Hematol 37 61–67 Occurrence Handle11164720
A Korfel C Oehm J Pawel Particlevon U Keppler M Deppermann S Kaubitsch E Thiel (2002) ArticleTitleResponse to topotecan of symptomatic brain metastases of small-cell lung cancer also after whole-brain irradiation: a multicentre phase II study Eur J Cancer 38 1724–1729 Occurrence Handle10.1016/S0959-8049(02)00140-5 Occurrence Handle12175688
PE Postmus H Haaxma-Reiche EF Smit HJM Groen H Karnicka T Lewinski J Meerbeeck Particlevan M Clerico A Gregor D Curran T Sahmoud A Kirkpatrick G Giaccone (2000) ArticleTitleTreatment of brain metastases of small-cell lung cancer: comparing teniposide and teniposide with whole-brain radiotherapy–a phase III study of the European Organization for the Research and Treatment of Cancer, Lung Cancer Cooperative Group J Clin Oncol 18 3400–3408 Occurrence Handle11013281
SE Kaba AP Kyritsis K Hess WK Yung R Mercier S Dakhil KA Jaeckle VA Levin (1997) ArticleTitleTPDC-FuHu chemotherapy for the treatment of recurrent metastatic brain tumors J Clin Oncol 15 1063–1070 Occurrence Handle9060546
L Crino GV Scagliotti S Ricci G Marinis ParticleDe M Rinaldi C Gridelli A Ceribelli R Bianco M Marangolo F Costanzo ParticleDi M Sassi S Barni A Ravaioli V Adamo L Portalone G Cruciani A Masotti G Ferrara F Gozzelino M Tonato (1999) ArticleTitleGemcitabine and cisplatin versus mitomycin, ifosfamide, and cisplatin in advanced non-small-cell lung cancer: a randomized phase III study of the Italian Lung Cancer Project J Clin Oncol 17 3522–3530 Occurrence Handle10550150
V Franciosi G Cocconi M Michiara F Di Costanzo V Fosser M Tonato P Carlini C Boni S Di Sarra (1999) ArticleTitleFront-line chemotherapy with cisplatin and etoposide for patients with brain metastases from breast, NSCLC or malignant melanoma: a prospective study Cancer 85 1599–1605 Occurrence Handle10.1002/(SICI)1097-0142(19990401)85:7<1599::AID-CNCR23>3.3.CO;2-R Occurrence Handle10193952
J Cortes J Rodriguez JM Aramendia E Salgado A Gurpide J Garcia-Foncillas JJ Aristu A Claver A Bosch JM Lopez-Picazo S Martin-Algarra A Brugarolas E Calvo (2003) ArticleTitleFront-line paclitaxel/cisplatin-based chemotherapy in brain metastases from non-small-cell lung cancer Oncology 64 28–35 Occurrence Handle10.1159/000066520 Occurrence Handle12457029
LE Abrey JD Olson JJ Raizer M Mack A Rodavitch DY Boutros (2001) ArticleTitleA phase II trial of temozolomide for patients with recurrent or progressive brain metastases J Neuro-Oncol 53 259–265 Occurrence Handle10.1023/A:1012226718323
C Christodoulou D Bafaloukos P Kosmidis E Samantas A Bamias P Papakostas A Karabelis C Bacoyiannis InstitutionalAuthorNameSkarlos DV for the Hellenic Cooperative Oncology Group (2001) ArticleTitlePhase II study of temozolomide in heavily pretreated cancer patients with brain metastases Ann Oncol 12 249–254 Occurrence Handle10.1023/A:1008354323167 Occurrence Handle11300333
R Dziadziuszko A Ardizzoni PE Postmus EF Smit A Price C Debruyne C Legrand InstitutionalAuthorName Giaccone G on behalf of the EORTC Lung Cancer Group (2003) ArticleTitleTemozolomide in patients with advanced non-small-cell lung cancer with and without brain metastases: a phase II study of the EORTC Lung Cancer Group (08965) Eur J Cancer 39 1271–1276 Occurrence Handle10.1016/S0959-8049(03)00234-X Occurrence Handle12763216
Y Ushio N Arita T Hayakawa H Mogami H Hasegawa S Bitoh Y Oku H Ikeda N Kanai M Kanoh (1991) ArticleTitleChemotherapy of brain metastases from lung carcinoma: a controlled randomized study Neurosurgery 28 201–205 Occurrence Handle10.1097/00006123-199102000-00005 Occurrence Handle1997887
G Robinet P Thomas JL Breton H Lena S Gouva G Dabouis J Bennouna PJ Souquet P Balmes L Thiberville P Fournel E Quoix R Riou P Rebattu M Perol D Paillotin F Mornex (2001) ArticleTitleResults of a phase III study of early versus delayed whole brain radiotherapy with concurrent cisplatin and vinorelbine combination in inoperable brain metastases of non-small-cell lung cancer: Groupe Francais de Pneumocancerologie (GFPC) protocol 95-1 Ann Oncol 12 59–67 Occurrence Handle10.1023/A:1008338312647 Occurrence Handle11249050
D Antonadou M Paraskevaidis G Sarris N Coliarakis I Economou P Karageorgis N Throuvalas (2002) ArticleTitlePhase II randomized trial of temozolomide and concurrent radiotherapy in patients with brain metastases J Clin Oncol 20 3644–3650 Occurrence Handle10.1200/JCO.2002.04.140 Occurrence Handle12202665
F Cappuzzo A Ardizzoni H Soto-Parra C Gridelli P Maione M Tiseo C Calandri S Bartolini A Santoro L Crinò (2003) ArticleTitleEpidermal growth factor receptor targeted therapy by ZD 1839 (Iressa) in patients with brain metastases from non-small-cell lung cancer (NSCLC) Lung Cancer 41 227–231 Occurrence Handle10.1016/S0169-5002(03)00189-2 Occurrence Handle12871787
D Rozner T Nemoto WW Lane (1986) ArticleTitleChemotherapy induces regression of brain metastases in breast carcinoma Cancer 58 832–839 Occurrence Handle3755076
W Boogerd O Dalesio EM Bais JJ Sande Particlevan der (1992) ArticleTitleResponse of brain metastases from breast cancer to systemic chemotherapy Cancer 69 972–980 Occurrence Handle1735089
G Cocconi R Lottici G Bisagni M Bacchi M Tonato R Passalacqua C Boni V Belsanti P Bassi (1990) ArticleTitleCombination therapy with platinum and etoposide of brain metastases from breast carcinoma Cancer Invest 8 327–334 Occurrence Handle2207757
M Colleoni C Graiff P Nelli G Vicario G Sgarbossa F Pancheri P Manente (1997) ArticleTitleActivity of combination chemotherapy in brain metastases from breast and lung adenocarcinoma Am J Clin Oncol 20 303–307 Occurrence Handle10.1097/00000421-199706000-00020 Occurrence Handle9167759
N Siegelmann-Danieli M Stein J Bar-Ziv (2003) ArticleTitleComplete response of brain metastases originating in breast cancer to capecitabine therapy Isr Med Assoc J 5 833–834 Occurrence Handle14650117
RW Carey JM Davis NT Zervas (1981) ArticleTitleTamoxifen-induced regression of cerebral metastases in breast carcinoma Cancer Treat Rep 65 793–795 Occurrence Handle6168372
H Pors FE Eyben Particlevon OS Sorensen M Larsen (1991) ArticleTitleLongterm remission of multiple brain metastases with tamoxifen J Neurooncol 10 173–177 Occurrence Handle10.1007/BF00146879 Occurrence Handle1716670
M Salvati L Cervoni G Innocenzi L Bardella (1993) ArticleTitleProlonged stabilization of multiple and single brain metastases from breast cancer with tamoxifen Report of three cases. Tumori 79 359–362
A Gaast Particlevan der J Alexieva-Figusch C Vecht J Verweij G Stoter (1990) ArticleTitleComplete remission of a brain metastasis to third-line hormonal treatment with megestrol acetate Am J Clin Oncol 13 507–509 Occurrence Handle2173393
P Lissoni S Barni A Ardizzoia G Tancini A Conti G Maestroni (1994) ArticleTitleA randomized study with the pineal hormone melatonin versus supportive care alone in patients with brain metastases due to solid neoplasms Cancer 73 699–701 Occurrence Handle8299092
JC Bendell SM Domchek HJ Burstein L Harris J Younger I Kuter C Bunnell M Rue R Gelman E Winer (2003) ArticleTitleCentral nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma Cancer 97 2972–2977 Occurrence Handle10.1002/cncr.11436 Occurrence Handle12784331
E Shmueli N Wigler M Inbar (2004) ArticleTitleCentral nervous system progression among patients with metastatic breast cancer responding to trastuzumab treatment Eur J Cancer 40 379–382 Occurrence Handle10.1016/j.ejca.2003.09.018 Occurrence Handle14746856
DG Kirsch FH Hochberg (2003) ArticleTitleTargeting HER2 in brain metastases from breast cancer Clin Cancer Res 9 5435–5436 Occurrence Handle14654521
SD Fossa C Bokemeyer A Gerl S Culine WG Jones GM Mead JR Germa-Luch J Pont HJ Schmoll S Tjulandin (1999) ArticleTitleTreatment outcome of patients with brain metastases from malignant germ cell tumors Cancer 85 988–997 Occurrence Handle10.1002/(SICI)1097-0142(19990215)85:4<988::AID-CNCR29>3.0.CO;2-R Occurrence Handle10091779
ES Newlands KD Bagshawe RH Begent GJ Rustin L Holden (1991) ArticleTitleResults with the EMA/CO (etoposide, methotrexate, actinomycin D, cyclophosphamide, vincristine) regimen in high risk gestational trophoblastic tumours, 1979 to 1989 Br J Obstet Gynaecol 98 550–557 Occurrence Handle1651757
KG Cooper HC Kitchener DE Parkin (1994) ArticleTitleCerebral metastases from epithelial ovarian carcinoma treated with carboplatin Gynecol Oncol 55 318–323 Occurrence Handle10.1006/gyno.1994.1297 Occurrence Handle7959302
LE Abrey JO Dalmau (1999) ArticleTitleNeurologic complications of ovarian carcinoma Cancer 85 127–133 Occurrence Handle10.1002/(SICI)1097-0142(19990101)85:1<127::AID-CNCR18>3.0.CO;2-7 Occurrence Handle9921984
C Jacquillat D Khayat P Banzet M Weil P Fumoleau MF Avril M Namer J Bonneterre P Kerbrat JJ Bonerandi (1990) ArticleTitleFinal report of the French multicenter phase II study of the nitrosourea fotemustine in 153 evaluable patients with disseminated malignant melanoma including patients with cerebral metastases Cancer 66 1873–1878 Occurrence Handle2224783
MR Middleton JJ Grob N Aaronson G Fierlbeck W Tilgen S Seiter M Gore S Aamdal J Cebon A Coates B Dreno M Henz D Schadendorf A Kapp J Weiss U Fraass P Statkevich M Muller N Thatcher (2000) ArticleTitleRandomized phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma J Clin Oncol 18 158–166 Occurrence Handle10623706
G Biasco MA Pantaleo S Casadei (2001) ArticleTitleTreatment of brain metastases of malignant melanoma with temozolomide N Eng J Med 345 621–622 Occurrence Handle10.1056/NEJM200108233450817
H Nakagawa T Fujita S Izumimoto Y Miyawaki S Kubo Y Nakajima K Tsuruzono K Kodama M Higashiyama O Doi (1993) ArticleTitlecis-diamminedichloroplatinum (CDDP) therapy for brain metastasis of lung cancer II: Clinical effects. J Neurooncol 16 69–76
R Soffietti R Ruda R Mutani (2002) ArticleTitleManagement of brain metastases J Neurol 249 1357–1369 Occurrence Handle10.1007/s00415-002-0870-6 Occurrence Handle12382150
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Soffietti, R., Costanza, A., Laguzzi, E. et al. Radiotherapy and chemotherapy of brain metastases. J Neurooncol 75, 31–42 (2005). https://doi.org/10.1007/s11060-004-8096-3
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DOI: https://doi.org/10.1007/s11060-004-8096-3