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Structural and functional cerebellar impairment in the progeny of preeclamptic rat mothers

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Abstract

It is known that preeclampsia alters the neurodevelopment of the descent of preeclamptic mothers. Given that cerebellar development occurs mainly when the brain in gestation is impacted by the preeclampsia, and it is described that in preeclampsia exist a placental dysregulation of pro- and anti-angiogenic factors, such as vascular endothelial growth factor and its main receptors: VEGF receptor 2 phosphorylated at Y951 and VEGF receptor 2 phosphorylated at Y1172, we decided to evaluate, the effect of experimental preeclampsia on the cerebellar expression of VEGF and two of its receptors, pY951 VEGF R2 and pY1172 VEGF R2. This evaluation was carried out in the progeny of preeclamptic mothers in an ontogenetic stage equivalent to infancy, using the experimental model of preeclampsia based on the administration of N (ω)-nitro-L-arginine methyl ester in pregnant Sprague–Dawley rats. As part of our assessment of the functional correlate of the cerebellum, we evaluated the balance and locomotor learning in the progeny using the rotarod test. We observed that experimental preeclampsia increased the blood pressure in the mothers, along with proteinuria and the alteration of the level of vascular endothelial growth factor in the cerebellar vermis of both sexes progeny. Furthermore, it was observed an increase VEGF receptor 2 phosphorylated at Y951 in the male progeny. Additionally, it was observed a decrease in locomotor learning among daughters of preeclamptic mothers. Future studies are necessary to continue understanding the complex pathophysiology of preeclampsia and how it affects the neurodevelopment of the offspring.

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Acknowledgements

We want to thank for the support received from Escuela de Kinesiología, Pontificia Universidad Católica de Valparaíso, Chile.

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This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector. The authors have no relevant financial or non-financial interests to disclose.

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  1. Escuela de Kinesiología, Facultad de Ciencias, Pontificia Universidad Católica de Valparaíso, Avenida Universidad #, 2340000, Valparaíso, V Region, Chile

    Martina Valencia-Narbona, Eloísa Torres, Fernanda Muñoz & Trinidad García

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  1. Martina Valencia-Narbona
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  2. Eloísa Torres
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  3. Fernanda Muñoz
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  4. Trinidad García
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All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Martina Valencia-Narbona, Eloísa Torres, Fernanda Muñoz and Trinidad García. The first draft of the manuscript was written by Martina Valencia-Narbona and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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All procedures were performed according to protocols similar to the standards used in the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards and were approved by “Pontificia Universidad Católica de Valparaíso” Bioethics Committee.

Approval was obtained from the ethics committee of University Pontificia Universidad Católica de Valparaíso. The procedures used in this study adhere to the tenets of the Declaration of Helsinki.

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In Brief

Effect of experimental preeclampsia on locomotor learning and differential cerebellar expression of the vascular endothelial growth factor and its receptors in the female and male infant progeny of preeclamptic mothers.

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Valencia-Narbona, M., Torres, E., Muñoz, F. et al. Structural and functional cerebellar impairment in the progeny of preeclamptic rat mothers. Neurosci Behav Physi 53, 1283–1299 (2023). https://doi.org/10.1007/s11055-023-01503-8

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