Individual behavioral characteristics in rats in an open field test characterizing their resistance to emotional stress had significant influences on the severity of neurological symptomatology in intracerebral hemorrhage. Rats predicted to be resistant to stress were characterized by faster recovery of neurological status and motor and coordination impairments by day 7 after unilateral hemorrhagic stroke in the caudate nucleus than stress-susceptible rats. Changes in vessels and neurons in the contralateral sensorimotor cortex were more marked after caudate nucleus hemorrhagic stroke in stress-susceptible animals than in stress-resistant animals, while capillary neogenesis was not seen in the former group. By day 7 of poststress hemorrhagic stroke in the caudate nucleus, stress-resistant rats, unlike stress-susceptible animals, showed compensatory mechanisms in the sensorimotor cortex contralateral to the stroke, which is evidence for the possible recovery of structures and normal neuron functioning.
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References
E. V. Koplik, I. V. Gannushkina, A. L. Antelava, et al., “Prognostic behavioral criteria and characteristics of brain blood flow in rats with different levels of resistance to emotional stress,” Fiziol. Zh., 81, No. 9, 35–39 (1995).
E. V. Koplik, I. V. Gannushkina, A. L. Antelava, et al., “Resistance to emotional stress and cerebral ischemia in rats,” Proceeding for Natural Sciences. Matica Srpska Novi Sad, 95, 17–23 (1999).
N. V. Vereshchagin and N. V. Piradov, “Stroke: assessment of the problem,” Nevrol. Zh., 4, No. 5, 4–7 (1999).
M. M. Odinak, A. A. Mikhailenko, Yu. S. Ivanov, and G. F. Semin, Vascular Diseases of the Brain [in Russian], Gippokrat, St. Petersburg (2003).
Z. A. Suslina, L. A. Geraksina, and A. V. Fonyakin, Arterial Hypertension, Vascular Pathology of the Brain, and Antihypertensive Treatment [in Russian], Moscow (2006).
N. K. Bogolepov, Cerebral Crises and Stroke [in Russian], Meditsina, Moscow (1971).
E. V. Koplik, “A method for assessing a criterion of the resistance of rats to emotional stress,” Zh. Vestn. Nov. Met. Tekhnol., 9, No. 1, 16–18 (2002).
E. A. Yumatov, E. I. Pevtsova, and L. A. Mezentseva, “A physiologically appropriate experimental model of aggression and emotional stress,” Zh. Vyssh. Nerv. Deyat., 38, 350–354 (1988).
W. Deinsberger, J. Vogel, W. Kuschinsky, et al., “Experimental intracerebral hemorrhage: description of a double injection model in rats,” Neurol. Res., 18, 475–477 (1996).
Hua Ya, T. Schallert, R. F. Keep, et al., “Behavioral tests after intracerebral hemorrhage in rats,” Stroke, 33, 2478–2484 (2002).
P. Lipton, “Ischemic cell death in brain neurons,” Physiol. Rev., 79, No. 4, 1431–1568 (1999).
V. V. Kupriyanov, V. F. Mironov, A. A. Mironov, and O. V. Churina, Angiogenesis: Formation, Growth, and Development of Blood Capillaries [in Russian], NIS Kvartet, Moscow (1993).
K. Gora-Kupilas and J. Josko, “The neuroprotective function of vascular endothelial growth factor (VEGF),” Folia Neuropathol., 43, No. 1, 31–39 (2005).
N. N. Bogolepov, E. N. Popova, E. V. Koplik, and G. N. Krivitskaya, “Structural-functional characteristics of sensorimotor cortex neurons in rats with different levels of resistance to emotional stress,” Byull. Eksperim. Med., 132, No. 8, 124–128 (2001).
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Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 109, No. 10, Stroke, Iss. 2, pp. 39–46, October, 2009.
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Ivannikova, N.O., Koplik, E.V., Popova, E.N. et al. Emotional stress in the development of experimental hemorrhagic stroke in rats with different levels of stress resistance. Neurosci Behav Physi 41, 35–41 (2011). https://doi.org/10.1007/s11055-010-9375-4
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DOI: https://doi.org/10.1007/s11055-010-9375-4