Abstract
The prevalence of attention deficit hyperactivity disorder (ADHD) in young schoolchildren in Nefteyugansk (Khanty-Mansiiskii Autonomous Region) was found to be 8%, with rates of 13% amongst boys and 3% amongst girls. Clinical investigation of a cohort of 122 children aged 6–11 years identified risk factors for the formation of ADHD as perinatal CNS injuries, inherited predisposition, and unfavorable social-psychological influences. Neuropsychological, neurophysiological (electroencephalography), and biochemical studies identified minor neurological abnormalities, some characteristic features of the motor and emotional spheres, and changes in higher mental functions. In addition, biochemical changes consisting of decreases in plasma and erythrocyte magnesium levels and decreases in Mg2+-ATPase activity were identified. Treatment with MAGNE-B6 allowed correction of many of these changes.
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References
I. P. Antonov and G. G. Shan’ko, Hyperkinesia in Children. Questions of Etiology, Pathogenesis, Treatment [in Russian], Nauka, Minsk (1975), pp. 159–160.
Yu. I. Barashnev, N. I. Bubnova, Z. Kh. Sorokina, et al., “Perinatal brain pathology: Risk limits and immediate and long-term prognoses,” Ros. Vestn. Perinatol. Pediat., 4, 6–12 (1998).
E. D. Belousova, A System for Assessing Neuropsychological and Neurological Impairments in Children with Minimal Brain Dysfunctions Using Data from Computer Tomography Scans of the Brain [in Russian], Author’s abstract of thesis for doctorate in medical sciences, Moscow (1994).
N. V. Grigor’eva, Clinical-Electroencephalographic Studies of Childhood Hyperactivity Attention Deficit [in Russian], Author’s abstract of thesis for doctorate in medical sciences, Moscow (1999).
N. N. Zavadenko, How to Understand the Child: Children with Hyperactivity and Attention Deficit [in Russian], Moscow (2001), Second edition.
I. Lesny, Clinical Methods for Neurological Investigations in Children [translated from Czech], Moscow (1987).
M. Lüscher, The Lüscher Color Test [translated from English by A. Nikonova], Sova, St. Petersburg and ÉKSMO Press, Moscow (2002).
I. V. Ravich-Shcherbo, T. M. Maryutina, and E. K. Grigorenko, Psychogenetics [in Russian], Moscow (1999).
T. M. Radaeva and A. M. Radaev, “Disintegration of the regulatory systems of the brain in the pathogenesis of minimal cerebral dysfunction,” in: Proceedings of the Seventh All-Russia Congress of Neurologists [in Russian], Nizhnyi Novgorod (1995).
É. G. Simernitskaya, I. A. Skvortsov, L. I. Moskovichyute, et al., A Method for Adaptive Neuropsychological Investigations for Pediatric Neuropathologists. Methodological Recommendations [in Russian], Moscow (1998).
A. B. Sorokin, N. V. Grigor’eva, N. N. Zavadenko, and N. L. Gorbachevskaya, “Neurophysiological studies of attention deficit disorder by quantitative EEG analysis,” Sib. Vestn. Psikhiat. Narkol., 1, No. 27, 47–49 (2003).
O. V. Khaletskaya and V. M. Troshin, Minimal Brain Dysfunction in Childhood [in Russian], Nizhnyi Novgorod (1995).
T. M. Achenbach, Manual for the Child Behavior Checklist. 4–18 and 1991 Profile, University of Vermont Department of Psychiatry, Burlington, VT (1991).
R. A. Barkley, “Behavioral inhibition, sustained attention and executive functions: constructing a unifying theory of attention deficit hyperactivity disorder,” Psychopharm. Bull., 121, No. 1, 65–84 (1997).
D. P. Cantwell, “Attention deficit disorder in adolescent,” Clin. Psychological. Rev., 6, 237–247 (1986).
M. Denckla, “Revised neurological examination for subtle signs,” Psychopharm. Bull., 21, 773–789 (1985).
B. S. Maher, M. L. Marazita, H. B. Moss, et al., “Segregation analysis of attention deficit hyperactivity disorder,” Amer. J. Med. Genet., 88, No. 1, 71–78 (1999).
S. Mannuzza et al., “Hyperactive boys almost grown up; II: status of subjects without a mental disorder,” Arch. Gen. Psychiat., 45, 13–18 (1988).
Sh. Milberger, J. Biederman, S. V. Faraone, et al, “Pregnancy, delivery, and infancy complications and Attention Deficit Hyperactivity Disorder: issues of gene-environment interaction,” Biol. Psychiat., 41, 65–75 (1997).
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Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 106, No. 2, pp. 17–20, February, 2006.
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Nogovitsina, O.R., Levitina, E.V. Neurological aspects of the clinical features, pathophysiology, and corrections of impairments in attention deficit hyperactivity disorder. Neurosci Behav Physiol 37, 199–202 (2007). https://doi.org/10.1007/s11055-007-0001-z
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DOI: https://doi.org/10.1007/s11055-007-0001-z