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A review on comparative study of PPI and PAMAM dendrimers

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Abstract

Dendrimers are hyperbranched, monodispersed macromolecules with multivalent functional end groups. Dendrimers have been explored as carrier for many drugs like anticancer, antiviral, antimalarial, antiprotozoal, anti tubercular drugs. Although a number of different types of dendrimers containing different core molecules, branching monomers and surface functional groups have been designed till date for drug delivery applications, yet the poly(propyleneimine) (PPI) and poly(amidoamine) (PAMAM) dendrimers have been the most explored dendrimers in this regard. In this review, we have summarized a comparative data on PPI and PAMAM dendrimers particularly relevant to their properties, synthesis, toxicity, biomedical applications and drug delivery attributes.

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Authors and Affiliations

  1. Pharmaceutical Nanotechnology Research Laboratory, ISF College of Pharmacy, Moga, Punjab, 142001, India

    Daljeet Kaur, Keerti Jain, Neelesh Kumar Mehra & Narendra K. Jain

  2. National Institute of Pharmaceutical Education and Research (NIPER Raebareli), Raebareli, Uttar Pradesh, 229010, India

    Keerti Jain

  3. Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A & M Health Science Center, Texas A & M University, Kingsville, TX, USA

    Neelesh Kumar Mehra

  4. Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, 48201, USA

    Prashant Kesharwani

  5. School of Pharmaceutical Sciences, Rajiv Gandhi Technical University, Airport Bypass Road, Gandhi Nagar, Bhopal, Madhya Pradesh, 462036, India

    Narendra K. Jain

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  1. Daljeet Kaur
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Kaur, D., Jain, K., Mehra, N.K. et al. A review on comparative study of PPI and PAMAM dendrimers. J Nanopart Res 18, 146 (2016). https://doi.org/10.1007/s11051-016-3423-0

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