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Chaetomium globosum Cutaneous Fungal Infection Confirmed by Molecular Identification: A Case Report from Malaysia

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Abstract

An 11-year-old girl presented with multiple blisters on her the right foot complicated with cellulitis. The conventional and molecular identification were performed on the culture. The internal transcribed spacer (ITS) region in rRNA gene of the isolate was amplified by PCR. The sequence of the amplified ITS region matched 99 % with that of Chaetomium globosum in the GenBank. This is the first report describing C. globosum causing cutaneous infection in Malaysia.

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References

  1. Kim DM, Lee MH, Suh MK, Ha GY, Kim H, Choi JS. Onychomycosis Caused by Chaetomium globosum. Ann Dermatol. 2013;24(2):232–6.

    Article  Google Scholar 

  2. Kaliamurthy J, Kalavathy CM, Jesudasan CAN, Thomas PA. Case report. Keratitis due to Chaetomium sp. Ophthalmol Med. 2011;Article ID 696145:3 pages.

  3. Costa AR, Porto E, Lacaz S, de Melo NT, Calux JF, Valente NYS. Cutaneous and ungual phaeohyphomycosis caused by species of Chaetomium Kunze (1817) ex Fresenius, 1829. J Med Vet Mycol. 1988;26:261–8.

    Article  CAS  PubMed  Google Scholar 

  4. Yu J, Yang S, Zhao Y, Li R. A case of subcutaneous phaeohyphomycosis caused by Chaetomium globosum and the sequences analysis of C. globosum. Med Mycol. 2006;44:541–5.

    Article  CAS  PubMed  Google Scholar 

  5. Paterson PJ, Seaton S, Yeghen T, McHugh TD, McLaughlin J, Hoffbrand AV, Kibbler CC. Molecular confirmation of invasive infection caused by Chaetomium globosum. J Clin Pathol. 2005;58(3):334.

    CAS  PubMed Central  PubMed  Google Scholar 

  6. Abbott SP, Sigler L, McAleer R, et al. Fatal cerebral mycoses caused by the ascomycete Chaetomium strumarium. J Clin Microbiol. 1995;33:2692–8.

    CAS  PubMed Central  PubMed  Google Scholar 

  7. von Arx JA, Guarro J, Figueras MJ. The ascomycete genus Chaetomium. Beih Nova Hedwig. 1986;84:1–162.

    Google Scholar 

  8. Schoch CL, Seifert KA, Huhndorf S, Robert V, Spouge JL, Levesque CA, Chen W. Nuclear ribosomal internal transcribed spacer (ITS) region as a universal DNA barcode marker for fungi. Proc Natl Acad Sci USA. 2012;109:6241–6.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  9. Kirk PM, Cannon PF, Minter DW, Stalpers JA. Dictionary of the fungi. 10th ed. Wallingford: CABI Publishing; 2008.

    Google Scholar 

  10. Fogle MR, Douglas DR, Jumper CA, Straus DC. Growth and mycotoxin production by Chaetomium globosum. Mycopathologia. 2007;164(1):49–56.

    Article  CAS  PubMed  Google Scholar 

  11. Aru A, Munk-Nielsen L, Federspiel BH. The soil fungus Chaetomium in the human paranasal sinuses. Eur Arch Otorhinolaryngol. 1997;244:350–2.

    Article  Google Scholar 

  12. Lesire V, Hazouard E, Dequin PF, Delain M, Therizol-Ferly M, Legras A. Possible role of Chaetomium globosum in infection after autologous bone marrow transplantation. Intensive Care Med. 1999;25:124–5.

    Article  CAS  PubMed  Google Scholar 

  13. Yeghen T, Fenelon L, Campbell CK, Warnok DW, Hoffbrand AV, Prentice HG, Kibbler CC. Chaetomium pneumonia in patient with acute myeloid leukaemia. J Clin Pathol. 1996;49:184–6.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  14. Thomas C, Mileusnic D, Carey RB, Kampert M, Anderson D. Fatal Chaetomium cerebritis in a bone marrow transplant patient. Hum Pathol. 1999;30:874–9.

    Article  CAS  PubMed  Google Scholar 

  15. Teixeira ABA, Trabasso P, Moretti-Branchini ML, Aoki FH, Vigorito AC, Miyaji M, Mikami Y, Takada M, Schreiber AZ. Phaeohyphomycosis caused by Chaetomium globosum in an allogeneic bone marrow transplant recipient. Mycopathologia. 2003;156:309–12.

    Article  CAS  PubMed  Google Scholar 

  16. Barron MA, Sutton DA, Veve R, et al. Invasive mycotic infections caused by Chaetomium perlucidum, a new agent of cerebral phaeohyphomycosis. J Clin Microbiol. 2003;41:5302–7.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  17. Kumeda Y, Asao T. Single-strand confirmation polymorphism analysis of PCR-amplified ribosomal DNA internal transcribed spacer to differentiate species of Apergillus section Flavi. Appl Environ Microbiol. 1996;62:2947–52.

    CAS  PubMed Central  PubMed  Google Scholar 

  18. Williams DW, Wilson MJ, Lewis MA, Potts AJ. Identification of Candida species by PCR and restriction fragment length polymorphism analysis of intergenic spacer regions of ribosomal DNA. J Clin Microbiol. 1995;33:2476–9.

    CAS  PubMed Central  PubMed  Google Scholar 

  19. Aggarwal R, Kharbikar LL, Sharma S, Gupta S, Yadav A. Phylogenetic relationships of Chaetomium isolates based on the internal transcribed spacer region of the rRNA gene cluster. Afr J Biotechnol. 2013;12(9):914–20.

    CAS  Google Scholar 

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Acknowledgments

The authors would like to thank the Director General of Health, Malaysia, and the Director of Institute for Medical Research for permission to publish this article. We would also like to acknowledge the Department of Pathology, Selayang Hospital, for providing the fungal isolate.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical standard

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Authors and Affiliations

  1. Bacteriology Unit, Infectious Diseases Research Center, Institute for Medical Research, Jalan Pahang, 50588, Kuala Lumpur, Malaysia

    Ratna Mohd Tap, Parameswari Sabaratnam, Mohd Fuat Abd Razak, Rohaidah Hashim & Norazah Ahmad

  2. Dermatology Department, Selayang Hospital, Lebuhraya Selayang-Kepong, 68100, Batu Caves, Selangor, Malaysia

    Nur Ashikin Ahmad

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  1. Ratna Mohd Tap
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  2. Parameswari Sabaratnam
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  3. Nur Ashikin Ahmad
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  4. Mohd Fuat Abd Razak
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  5. Rohaidah Hashim
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  6. Norazah Ahmad
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Correspondence to Ratna Mohd Tap.

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Mohd Tap, R., Sabaratnam, P., Ahmad, N.A. et al. Chaetomium globosum Cutaneous Fungal Infection Confirmed by Molecular Identification: A Case Report from Malaysia. Mycopathologia 180, 137–141 (2015). https://doi.org/10.1007/s11046-015-9890-5

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  • DOI: https://doi.org/10.1007/s11046-015-9890-5

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