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Roles of microRNAs and exosomes in Helicobacter pylori associated gastric cancer

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Abstract

Helicobacter pylori (H. pylori) is a common pathogen that infects more than half of the world’s population. Its infection can not only lead to a variety of gastrointestinal diseases, such as chronic gastritis and gastric cancer (GC) but also be associated with many extra-gastrointestinal diseases. Exosomes, as a new intercellular information transmission medium, can carry biological signal molecules such as microRNAs (miRNAs) to regulate a variety of cellular physiological activities and are involved in multiple cancer processes. In this article, we provide a systematic review on the role of exosomal miRNAs in H. pylori-associated GC.

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Funding

This work was supported by the National Natural Science Foundation of China (No. 82102398), Shandong Provincial Natural Science Foundation (ZR2020QC073 and ZR2021MH409), and the 2019 Technology Development Project of Shandong Medicine and Health Science (2019WS230).

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Author notes

  1. Xiao-Han Xu and Shu-Li Shao have contributed equally to this work.

Authors and Affiliations

  1. School of Medical Laboratory, Weifang Medical University, Weifang, Shandong, 261053, People’s Republic of China

    Xiao-Han Xu & Zan Wang

  2. Department of Central Lab, Weihai Municipal Hospital, Weihai, Shandong, 264200, People’s Republic of China

    Shu-Li Shao, Dong Guo & Peng Liu

  3. School of Laboratory Medicine, Dalian Medical University, Dalian, Liaoning, 116044, People’s Republic of China

    Li-Na Ge

  4. Department of Laboratory Medicine, Affiliated Hospital of Weifang Medical University, Weifang, Shandong, 261031, People’s Republic of China

    Yuan-Yong Tao

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  1. Xiao-Han Xu
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  3. Dong Guo
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Contributions

Y.T. established the original concept and design. X.X., S.S., D.G., Z.W., L.G., and P.L. conducted literature retrieval. X.X., S.S., and Y.T. wrote the manuscript, designed the figures, and made critical revisions to the manuscript. D.G., L.G., Z.W., and P.L. helped with the discussion and corrected the text. All authors read and approved the final draft.

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Correspondence to Yuan-Yong Tao.

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Xu, XH., Shao, SL., Guo, D. et al. Roles of microRNAs and exosomes in Helicobacter pylori associated gastric cancer. Mol Biol Rep 50, 889–897 (2023). https://doi.org/10.1007/s11033-022-08073-x

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