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The role of aquaporin 4 in brain tumors: implications for pathophysiology, diagnosis and therapy

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Abstract

Primary brain tumors are a heterogeneous group of tumors that arise from cells intrinsic to the central nervous system (CNS). Aquaporin-4 (AQP4) has been implicated in the pathogenesis of brain tumors. Previous reports have documented a relationship between AQP4 and several molecular pathways associated with the etiology of brain tumors, such as apoptosis, invasion and cell migration. AQP4 affects apoptosis via cytochrome C, Bad and Bcl-2, as well as invasion and migration via IDO1/TDO–Kyn–AhR axis, lncRNA LINC00461, miR-216a, miRNA-320a and MMPs. In addition, inhibition of AQP4 mitigates the progression of brain tumors. This review summarizes current knowledge and evidence regarding the relationship between AQP4 and brain tumors, and the mechanisms involved.

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Authors and Affiliations

  1. Student Research Committee, Kashan University of Medical Sciences, Kashan, I.R. of Iran

    Mohammad Behnam & Fatemeh Zahra Rashidi Noshabad

  2. Department of Internal Medicine, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, I.R. of Iran

    Alireza Motamedzadeh

  3. Department of Radiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, I.R. of Iran

    Marzieh Aalinezhad

  4. Behavioral Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, I.R. of Iran

    Ehsan Dadgostar

  5. Student Research Committee, Isfahan University of Medical Sciences, Isfahan, I.R. of Iran

    Ehsan Dadgostar

  6. Student Research Committee, Jiroft University of Medical Sciences, Jiroft, I.R. of Iran

    Mohammad Pourfridoni

  7. Faculty of Medicine, Sari Branch, Islamic Azad University, Sari, I.R. of Iran

    Maedeh Raei

  8. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, I.R. of Iran

    Hamed Mirzaei

  9. Department of Molecular Pharmacology, Albert Einstein College of Medicine, 10461, Bronx, NY, USA

    Michael Aschner

  10. Electrophysiology Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, I.R. of Iran

    Omid Reza Tamtaji

  11. Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, I.R. of Iran

    Omid Reza Tamtaji

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MB, AM, MA, ED, FZ-RN, MP, MR, HM, MA and O-RT contributed in the conception or design of the work and drafting of the manuscript. All authors confirmed the final version for submission.

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Behnam, M., Motamedzadeh, A., Aalinezhad, M. et al. The role of aquaporin 4 in brain tumors: implications for pathophysiology, diagnosis and therapy. Mol Biol Rep 49, 10609–10615 (2022). https://doi.org/10.1007/s11033-022-07656-y

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