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PER2: a potential molecular marker for hematological malignancies

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Abstract

Circadian rhythm is a periodic change of organism according to the law of external environment, which is manifested in metabolism, cell proliferation, physiology and behavior. In recent years, the role of circadian genes in the occurrence and progression of hematological malignancies have been continuously demonstrated. PER2 is the core component of the circadian rhythm playing an important role in regulating the circadian rhythm of the biological clock. This review summarizes the research progress of PER2 in hematological malignancies, especially leukemia, in order to better understand its role in hematological malignancies, and provide new ideas for clinical diagnosis and treatment.

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Funding

This work was supported by Major scientific and technological innovation projects of Shandong Province of China (Grant No. 2019JZZY011018), Yantai Science and Technology Plan Project of China (Grant No. 2019MSGY133) and Yantai Science and Technology Plan Project of China (Grant No. 2019YD004).

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Author notes

  1. Huihui Jiang and Xin Yang have contributed equally to this study.

Authors and Affiliations

  1. Department of Laboratory Center, Yantai Yuhuangding Hospital Affiliated to Qingdao University, 20 Yuhuangding East Road, Yantai, 264000, Shandong, China

    Huihui Jiang, Xin Yang, Miaomiao Mi, Hongyuan Wu & Chengming Sun

  2. Department of Laboratory Center, Qingdao Women and Children’s Hospital, Qingdao, 266000, Shandong, China

    Xiaonan Wei

  3. Binzhou Medical University, Yantai, 264000, Shandong, China

    Yu Xin

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  1. Huihui Jiang
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Contributions

HJ and XY had the idea for the review and wrote the first draft of the manuscript. MM, XW performed the literature search. HW and YX collected data. CS critically revised the work. All authors have read and approved the manuscript, and all authors commented on previous versions of the manuscript.

Corresponding author

Correspondence to Chengming Sun.

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The authors declare that they have no conflict of interest.

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Jiang, H., Yang, X., Mi, M. et al. PER2: a potential molecular marker for hematological malignancies. Mol Biol Rep 48, 7587–7595 (2021). https://doi.org/10.1007/s11033-021-06751-w

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