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Association between BH3 interacting domain death agonist (BID) gene polymorphism and ossification of the posterior longitudinal ligament in Korean population

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Abstract

The purpose of this study was to investigate single nucleotide polymorphisms (SNPs) of the BH3 interacting domain death agonist (BID) gene as a risk factor in Korean patients with ossification of the posterior longitudinal ligament (OPLL). To investigate the genetic association, two coding SNPs (rs8190315, Ser10Gly; rs2072392, Asp60Asp) of BID were genotyped in 157 OPLL patients and 209 control subjects. SNPStats, SNPAnalyzer Pro, Helixtree, and Haploview 4.2 programs were used for association analysis. Multiple logistic regression models (codominant, dominant, and recessive) were calculated for the odds ratios (ORs), 95 % confidence intervals (CIs), and corresponding P values. For multiple testing, Bonferroni correction was performed. After Bonferroni correction, genotype analysis of both rs8190315 and rs2072392 showed association between the OPLL group and the control group in the codominant model (P = 0.042, OR 1.86, 95 % CI 1.10–3.15). A complete linkage disequilibrium block was estimated between the two SNPs. Both of the G allele of rs8190315 and C allele of rs2072392 were strongly associated with an increased risk in the development of OPLL (P = 0.0052, OR 2.66, 95 % CI 1.51–4.68). These results suggest that BID is associated with OPLL, and both the G allele of a missense SNP (rs8190315, Ser10Gly) and C allele of a synonymous SNP (rs2072392, Asp60Asp) are risk factors for the development of OPLL in Korean population.

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Physical Medicine & Rehabilitation, College of Medicine, Kyung Hee University, Seoul, 130-701, Republic of Korea

    Jinmann Chon, Jang-Hyeok Hong, Jinsung Kim, Yoo Jin Han, Dong Hwan Kim, Seung Don Yoo, Hee-Sang Kim & Dong Hwan Yun

  2. Department of Biochemistry and Molecular Biology, Kyung Hee University, Seoul, 130-701, Republic of Korea

    Byoung Wook Lee

  3. Department of Thoracic and Cardiovascular Surgery, College of Medicine, Kyung Hee University, Seoul, 130-701, Republic of Korea

    Soo-Cheol Kim

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  1. Jinmann Chon
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Correspondence to Dong Hwan Yun.

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Jinmann Chon and Jang-Hyeok Hong contributed equally to this work.

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Chon, J., Hong, JH., Kim, J. et al. Association between BH3 interacting domain death agonist (BID) gene polymorphism and ossification of the posterior longitudinal ligament in Korean population. Mol Biol Rep 41, 895–899 (2014). https://doi.org/10.1007/s11033-013-2933-4

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  • DOI: https://doi.org/10.1007/s11033-013-2933-4

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