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Transcriptional regulation of the survivin gene

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Abstract

Survivin, a small member of the inhibitors of the apoptosis protein family, is highly deregulated in cancer. It is weakly expressed in normal tissues but very strongly expressed in malignant lesions. Survivin is involved in cell-cycle progression, especially in the G2/M transition, and has anti-apoptotic activity, which correlates with its strong expression in cases with a poor cancer treatment response and poor outcomes. Several therapies that target the survivin transcript or protein are currently being tested in clinical trials. However, focusing new therapies on the origins of survivin overexpression and targeting these upstream deregulations could be more effective. For this reason, it seems important to make an inventory of the transcriptional (de)regulation of survivin. This review will gather the important points concerning the regulation of survivin mRNA expression: structure of the survivin promoter, epigenetic modifications and genetic abnormalities, transcription factors, and signalling pathways that affect survivin mRNA expression.

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Acknowledgments

We thank Philip Bastable (CHU Le Bocage, Dijon, France) for editing the manuscript. RB was financially supported by the Ligue contre le Cancer de Côte d’Or and Ligue contre le Cancer de l’Yonne and FV was granted by the Ligue nationale contre le Cancer.

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The authors have no conflict of interest to declare.

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Authors and Affiliations

  1. Unit of Molecular Biology, Centre Georges-François Leclerc, 1, rue du Professeur Marion, 21079, Dijon Cedex, France

    Romain Boidot, Frédérique Végran & Sarab Lizard-Nacol

  2. Faculté de Médecine, Equipe AVENIR, Inserm U866, Dijon, France

    Frédérique Végran

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  1. Romain Boidot
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  2. Frédérique Végran
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Correspondence to Romain Boidot.

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Boidot, R., Végran, F. & Lizard-Nacol, S. Transcriptional regulation of the survivin gene. Mol Biol Rep 41, 233–240 (2014). https://doi.org/10.1007/s11033-013-2856-0

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