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Phloridzin reduces blood glucose levels and improves lipids metabolism in streptozotocin-induced diabetic rats

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Abstract

Phloridzin is the specific and competitive inhibition of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). This property which could be useful in the management of postprandial hyperglycemia in diabetes and related disorders. Phloridzin is one of the dihydrochalcones typically contained in apples and in apple-derived products. The effect of phloridzin orally doses 5, 10, 20 and 40 mg/kg body weight on diabetes was tested in a streptozotocin-induced rat model of diabetes type 1. From beneficial effect of this compound is significant reduction of blood glucose levels and improve dyslipidemia in diabetic rats. As a well-known consequence of becoming diabetic, urine volume and water intake were significantly increased. Administration of phloridzin reduced urine volume and water intake in a dose-dependent manner. Phloretin decreases of food consumption, as well as a marked lowering in the weight. In conclusion, this compound could be proposed as an antihyperglycemic and antihyperlipidemic agent in diabetes and potential therapeutic in obesity.

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Authors and Affiliations

  1. Department of Biology, Jahrom Branch, Islamic Azad University, Jahrom, Iran

    Mahmood Najafian, Mohammad Zareain Jahromi, Mohammad Javad Nowroznejhad, Parastoo Khajeaian, Mohammad Mehdi Kargar & Mehdi Sadeghi

  2. Department of Biology, Faculty of Science, Islamic Azad University, Rasht, Iran

    Amir Arasteh

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  1. Mahmood Najafian
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  2. Mohammad Zareain Jahromi
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  3. Mohammad Javad Nowroznejhad
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Correspondence to Mahmood Najafian.

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Najafian, M., Jahromi, M.Z., Nowroznejhad, M.J. et al. Phloridzin reduces blood glucose levels and improves lipids metabolism in streptozotocin-induced diabetic rats. Mol Biol Rep 39, 5299–5306 (2012). https://doi.org/10.1007/s11033-011-1328-7

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  • DOI: https://doi.org/10.1007/s11033-011-1328-7

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