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Three-component synthesis of benzo[b][1,5]thiazepines via coupling–addition–cyclocondensation sequence

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Abstract

2,4-Disubstituted benzo[b][1,5]thiazepines represent nonfluorescent intense yellow chromophores and are readily synthesized from acid chlorides, terminal alkynes, and ortho-amino thiophenols by a consecutive one-pot three-component Sonogashira coupling–Michael addition–cyclocondensation sequence under mild conditions in good yields.

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  1. Institut für Organische Chemie und Makromolekulare Chemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstraße 1, 40225, Düsseldorf, Germany

    Benjamin Willy & Thomas J. J. Müller

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Willy, B., Müller, T.J.J. Three-component synthesis of benzo[b][1,5]thiazepines via coupling–addition–cyclocondensation sequence. Mol Divers 14, 443–453 (2010). https://doi.org/10.1007/s11030-009-9223-z

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