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Integrated view of molecular diagnosis and prognosis of dengue viral infection: future prospect of exosomes biomarkers

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Abstract

Dengue viruses (DENVs) are the viruses responsible for dengue infection which affects lungs, liver, heart and also other organs of individuals. DENVs consist of the group of four serotypically diverse dengue viruses transmitted in tropical and sub-tropical countries of world. Aedes mosquito is the principal vector which spread the infection from infected person to healthy humans. DENVs can cause different syndromes depending on serotype of virus which range from undifferentiated mild fever to dengue hemorrhagic fever resulting in vascular leakage due to release of cytokine and Dengue shock syndrome with fluid loss and hypotensive shock, or other severe manifestations such as bleeding and organ failure. Increase in dengue cases in pediatric population is a major concern. Transmission of dengue depends on various factors like temperature, rainfall, and distribution of Aedes aegypti mosquitoes. The present review describes a comprehensive overview of dengue, pathophysiology, diagnosis, treatment with an emphasis on potential of exosomes as biomarkers for early prediction of dengue in pediatrics.

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Acknowledgements

R.R. thankful to Sir Ganga Ram Hospital, Delhi, India for providing the necessary support.

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  1. Department of Research, Sir Ganga Ram Hospital, New Delhi, 110060, India

    Rashmi Rana, Ravi Kant & Nirmal Kumar Ganguly

  2. Department of Pediatrics, Sir Ganga Ram Hospital, New Delhi, 110060, India

    Dinesh Kaul & Anil Sachdev

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Dr. RR and Prof. NKG contributed to the concept. Dr. RR, Mr. RK and Dr. DK wrote the manuscript. Dr. RR and Dr. AS edited the Manusript. The final version of the manuscript was read and approved by all authors.

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Rana, R., Kant, R., Kaul, D. et al. Integrated view of molecular diagnosis and prognosis of dengue viral infection: future prospect of exosomes biomarkers. Mol Cell Biochem 477, 815–832 (2022). https://doi.org/10.1007/s11010-021-04326-8

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