Abstract
Objectives
To evaluate the relationship between hypertensive (HTN) disorders and severe maternal morbidity (SMM). To understand whether there is differential prevalence of HTN disorders by race and whether the relationship between HTN disorders and SMM is modified by race and ethnicity.
Methods
We performed a retrospective cohort study using patient-level rates of SMM for pregnancies at all 61 non-military hospitals in Washington State from 10/2015 to 9/2016. Data were obtained from the Washington State Comprehensive Hospital Abstract Reporting System. Adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated to evaluate the association of HTN disorders and SMM (with and without transfusion) overall and by race. The population-attributable fraction of HTN disorders on SMM within each racial/ethnic group was calculated.
Results
Of 76,965 deliveries, 864 (1.1%) had any SMM diagnosis or procedure. All racial and ethnic minorities, except white and Asian, were disproportionally affected by preeclampsia with severe features (SF) and SMM. Overall, and within each racial/ethnic group, the SMM rate was higher among pregnancies with any HTN disorder compared to no HTN disorder (2.8 vs. 0.9%, OR 3.1, 95% CI 2.7–3.6). Race and ethnicity significantly modified the association. Overall and within each racial/ethnic group, there was a dose-response relationship between the type of HTN disorder and SMM, with more severe HTN disorders leading to a greater risk of SMM. The population-attributable fraction of HTN disorders on SMM was 20.6% for Black individuals versus 17.5% overall. The findings were similar when reclassifying transfusion-only SMM as no SMM.
Conclusions
In Washington, HTN disorders are associated with SMM in a dose-dependent fashion with the greatest impact among Black individuals.
Significance
Hypertensive disorders are a risk factor for SMM and hypertensive disorders and SMM occur disproportionately among marginalized populations.
AbstractSection What does this study add to what is already known?This study highlights that severe hypertensive disorders, especially preeclampsia with SF, disproportionately affect marginalized groups, and SMM appears to be disproportionately attributable to hypertensive disorders among people who identify as Black.
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Data Availability
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Code Availability
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References
ACOG Practice Bulletin No. 202: Gestational Hypertension and Preeclampsia (2019). Obstetrics and Gynecology, 133(1), e1–e25. https://doi.org/10.1097/AOG.0000000000003018.
Admon, L. K., Winkelman, T. N. A., Zivin, K., Terplan, M., Mhyre, J. M., & Dalton, V. K. (2018). Racial and ethnic disparities in the incidence of severe maternal morbidity in the United States, 2012–2015. Obstetrics and Gynecology, 132(5), 1158–1166. https://doi.org/10.1097/AOG.0000000000002937.
American College of Obstetricians and Gynecologists’ Committee on Practice Bulletins—Obstetrics. (2019). ACOG Practice Bulletin 203: Chronic hypertension in pregnancy. Obstetrics and Gynecology, 133(1), e26–e50. https://doi.org/10.1097/AOG.0000000000003020.
Ananth, C. V., Duzyj, C. M., Yadava, S., Schwebel, M., Tita, A. T. N., & Joseph, K. S. (2019). Changes in the prevalence of chronic hypertension in pregnancy, United States, 1970 to 2010. Hypertension (Dallas Tex : 1979), 74(5), 1089–1095. https://doi.org/10.1161/HYPERTENSIONAHA.119.12968.
Bateman, B. T., Bansil, P., Hernandez-Diaz, S., Mhyre, J. M., Callaghan, W. M., & Kuklina, E. V. (2012). Prevalence, trends, and outcomes of chronic hypertension: A nationwide sample of delivery admissions. American Journal of Obstetrics and Gynecology, 206(2), 134e1–134e8. https://doi.org/10.1016/j.ajog.2011.10.878.
Brown, C. C., Adams, C. E., George, K. E., & Moore, J. E. (2020). Associations between comorbidities and severe maternal morbidity. Obstetrics and Gynecology, 136(5), 892–901. https://doi.org/10.1097/AOG.0000000000004057.
Creanga, A. A., Bateman, B. T., Kuklina, E. V., & Callaghan, W. M. (2014). Racial and ethnic disparities in severe maternal morbidity: A multistate analysis, 2008–2010. American Journal of Obstetrics and Gynecology, 210(5), 435e1–435e8. https://doi.org/10.1016/j.ajog.2013.11.039.
Gadson, A., Akpovi, E., & Mehta, P. K. (2017). Exploring the social determinants of racial/ethnic disparities in prenatal care utilization and maternal outcome. Seminars in Perinatology, 41(5), 308–317. https://doi.org/10.1053/j.semperi.2017.04.008.
Go, A. S., Bauman, M. A., Coleman King, S. M., Fonarow, G. C., Lawrence, W., Williams, K. A., & Sanchez, E. (2014). An Effective Approach to high blood pressure control. Hypertension, 63(4), 878–885. https://doi.org/10.1161/HYP.0000000000000003.
Greenland, S., & Drescher, K. (1993). Maximum likelihood estimation of the attributable fraction from logistic models. Biometrics, 49(3), 865–872.
Guglielminotti, J., Wong, C. A., Friedman, A. M., & Li, G. (2021). Racial and ethnic disparities in death Associated with severe maternal morbidity in the United States: Failure to rescue. Obstetrics and Gynecology, 137(5), 791–800. https://doi.org/10.1097/AOG.0000000000004362.
Gupta, M., Greene, N., & Kilpatrick, S. J. (2018). Timely treatment of severe maternal hypertension and reduction in severe maternal morbidity. Pregnancy Hypertension, 14, 55–58. https://doi.org/10.1016/j.preghy.2018.07.010.
Hauspurg, A. (2021). Reducing maternal morbidity and racial disparities in Hypertension Care using an Automated Care Pathway. Obstetrics and Gynecology, 137(2), 209–210. https://doi.org/10.1097/AOG.0000000000004265.
Hitti, J., Sienas, L., Walker, S., Benedetti, T. J., & Easterling, T. (2018). Contribution of hypertension to severe maternal morbidity. American Journal of Obstetrics and Gynecology, 219(4), 405e1. 405.e7.
How Does CDC Identify Severe Maternal Morbidity?. CDC. (2023, July 3). https://www.cdc.gov/reproductivehealth/maternalinfanthealth/smm/severe-morbidity-ICD.htm.
Howell, E. A. (2018). Reducing disparities in severe maternal morbidity and mortality. Clinical Obstetrics and Gynecology, 61(2), 387–399. https://doi.org/10.1097/GRF.0000000000000349.
Howell, E. A., Egorova, N. N., Janevic, T., Brodman, M., Balbierz, A., Zeitlin, J., & Hebert, P. L. (2020). Race and ethnicity, Medical Insurance, and within-hospital severe maternal morbidity disparities. Obstetrics and Gynecology, 135(2), 285–293. https://doi.org/10.1097/AOG.0000000000003667.
Jain, J. A., Temming, L. A., D’Alton, M. E., Gyamfi-Bannerman, C., Tuuli, M., Louis, J. M., Srinivas, S. K., Caughey, A. B., Grobman, W. A., Hehir, M., Howell, E., Saade, G. R., Tita, A. T. N., & Riley, L. E. (2018). SMFM Special Report: Putting the M back in MFM: Reducing racial and ethnic disparities in maternal morbidity and mortality: A call to action. American Journal of Obstetrics and Gynecology, 218(2), B9–B17. https://doi.org/10.1016/j.ajog.2017.11.591.
Kilpatrick, S. J., Abreo, A., Greene, N., Melsop, K., Peterson, N., Shields, L. E., & Main, E. K. (2016). Severe maternal morbidity in a large cohort of women with acute severe intrapartum hypertension. American Journal of Obstetrics and Gynecology, 215(1), 91e1–91e7. https://doi.org/10.1016/j.ajog.2016.01.176.
Leonard, S. A., Main, E. K., Scott, K. A., Profit, J., & Carmichael, S. L. (2019). Racial and ethnic disparities in severe maternal morbidity prevalence and trends. Annals of Epidemiology, 33, 30–36. https://doi.org/10.1016/j.annepidem.2019.02.007.
Leonard, S. A., Kennedy, C. J., Carmichael, S. L., Lyell, D. J., & Main, E. K. (2020). An expanded Obstetric Comorbidity Scoring System for Predicting severe maternal morbidity. Obstetrics and Gynecology, 136(3), 440–449. https://doi.org/10.1097/AOG.0000000000004022.
Liese, K. L., Mogos, M., Abboud, S., Decocker, K., Koch, A. R., & Geller, S. E. (2019). Racial and ethnic disparities in severe maternal morbidity in the United States. Journal of Racial and Ethnic Health Disparities, 6(4), 790–798. https://doi.org/10.1007/s40615-019-00577-w.
MacDorman, M. F., Declercq, E., Cabral, H., & Morton, C. (2016). Recent increases in the U.S. maternal mortality rate: Disentangling Trends from Measurement issues. Obstetrics and Gynecology, 128(3), 447–455. https://doi.org/10.1097/AOG.0000000000001556.
MacDorman, M. F., Thoma, M., Declcerq, E., & Howell, E. A. (2021). Racial and ethnic disparities in maternal mortality in the United States using enhanced vital records, 2016–2017. American Journal of Public Health, 111(9), 1673–1681. https://doi.org/10.2105/AJPH.2021.306375.
Miranda, M. L., Swamy, G. K., Edwards, S., Maxson, P., Gelfand, A., & James, S. (2010). Disparities in maternal hypertension and pregnancy outcomes: Evidence from North Carolina, 1994–2003. Public Health Reports (Washington D C : 1974), 125(4), 579–587. https://doi.org/10.1177/003335491012500413.
Severe Maternal Morbidity in the United States | Pregnancy | Reproductive Health |CDC. (2020, January 31). https://www.cdc.gov/reproductivehealth/maternalinfanthealth/severematernalmorbidity.html.
Shahul, S., Tung, A., Minhaj, M., Nizamuddin, J., Wenger, J., Mahmood, E., Mueller, A., Shaefi, S., Scavone, B., Kociol, R. D., Talmor, D., & Rana, S. (2015). Racial disparities in Comorbidities, complications, and maternal and fetal outcomes in women with Preeclampsia/eclampsia. Hypertension in Pregnancy, 34(4), 506–515. https://doi.org/10.3109/10641955.2015.1090581.
Shields, L. E., Wiesner, S., Klein, C., Pelletreau, B., & Hedriana, H. L. (2017). Early standardized treatment of critical blood pressure elevations is associated with a reduction in eclampsia and severe maternal morbidity. American Journal of Obstetrics and Gynecology, 216(4), 415. https://doi.org/10.1016/j.ajog.2017.01.008.
Sienas, L., Albright, C. M., Walker, S., & Hitti, J. (2021). Severe Maternal Morbidity Associated with Hospital NICU Level in Washington State. American Journal of Perinatology, 38(13), 1335–1340. https://doi.org/10.1055/s-0041-1732452.
Tanaka, M., Jaamaa, G., Kaiser, M., Hills, E., Soim, A., Zhu, M., Shcherbatykh, I. Y., Samelson, R., Bell, E., Zdeb, M., & McNutt, L. A. (2007). Racial Disparity in Hypertensive Disorders of Pregnancy in New York State: A 10-Year Longitudinal Population-based study. American Journal of Public Health, 97(1), 163–170. https://doi.org/10.2105/AJPH.2005.068577.
Wang, E., Glazer, K. B., Howell, E. A., & Janevic, T. M. (2020). Social determinants of pregnancy-related mortality and morbidity in the United States: A systematic review. Obstetrics and Gynecology, 135(4), 896–915. https://doi.org/10.1097/AOG.0000000000003762.
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All authors contributed to the manuscript’s conceptualization, writing, and editing. Dr. Albright and Dr. Pike performed the statistical analysis.
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Albright, C.M., Sienas, L., Pike, M. et al. Racial Disparity in Severe Maternal Morbidity Associated with Hypertensive Disorders in Washington State: A Retrospective Cohort Study. Matern Child Health J (2024). https://doi.org/10.1007/s10995-024-03920-8
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DOI: https://doi.org/10.1007/s10995-024-03920-8