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Poly(vinyl pyrrolidone)–poloxamer-188 solid dispersions prepared by hot melt extrusion

Thermal properties and release behavior

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Abstract

Poly(vinyl pyrrolidone) (PVP)/poloxamer-188 blends were used as appropriate carriers for the preparation of solid dispersions by hot melt extrusion using aripiprazole (ARIP) as a poor water-soluble model drug. The physical state of ARIP in solid dispersions and its dissolution characteristics were tested for different drug contents and various PVP-to-poloxamer ratios. From TG analysis it was found that all materials were stable at the tested extrusion temperature conditions (110–120 °C) while amorphous drug dispersions were prepared in all cases, due to the miscibility of the polymer matrix with ARIP drug. Furthermore, hydrogen bonds were identified between ARIP (>N–H) and PVP (>C=O) using FT-IR analysis. Finally, ARIP dissolution rate from SDs was pH dependant and increased as the drug content decreased.

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Authors and Affiliations

  1. Laboratory of Polymer Technology, School of Chemical Engineering, National Technical University of Athens, 15780, Athens, Greece

    Emmanouil Fousteris & Petroula A. Tarantili

  2. Pharmathen S.A., Pharmaceutical Industry, Dervenakion Str 6, Pallini, 15351, Attiki, Greece

    Evangelos Karavas

  3. Laboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece

    Dimitrios Bikiaris

Authors
  1. Emmanouil Fousteris
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  2. Petroula A. Tarantili
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  3. Evangelos Karavas
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  4. Dimitrios Bikiaris
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Correspondence to Dimitrios Bikiaris.

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Fousteris, E., Tarantili, P.A., Karavas, E. et al. Poly(vinyl pyrrolidone)–poloxamer-188 solid dispersions prepared by hot melt extrusion. J Therm Anal Calorim 113, 1037–1047 (2013). https://doi.org/10.1007/s10973-012-2885-2

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  • DOI: https://doi.org/10.1007/s10973-012-2885-2

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