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Physico-chemical characterization and dissolution properties of nifluminic acid-cyclodextrin-PVP ternary systems

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Abstract

In view of the poor aqueous solubility of nifluminic acid (NIF), the aim of this article was to improve its solubility and dissolution rate through the preparation of formulations based on hydroxypropyl β-cyclodextrin (HPβCD) and polyvinylpyrrolidone K25 (PVP K25), a combination of carriers which has been advantageously used for a similar purpose with various hydrophobic drugs. Ternary systems of NIF, HPβCD, and PVP K25 were prepared in different drug to CD to PVP ratios by physical mixing, kneading, microwave irradiation, and co-evaporation. Differential scanning calorimetry, thermogravimetric analysis, hot stage microscopy, Fourier transform infrared spectroscopy, and X-ray powder diffractometry were used to investigate the resulting solid-state interactions. The results showed that the solid state of the drug in the amorphous or crystalline ternary combinations influenced both the solubility and the dissolution rate of NIF.

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Acknowledgements

This study was supported by TÁMOP research project: Development of teranostics in cardiovascular, metabolics, and inflammatory diseases (TÁMOP-4.2.2-08/1-2008-0013).

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Authors and Affiliations

  1. Department of Pharmaceutical Technology, University of Szeged, 6720, Eötvös u. 6, Szeged, Hungary

    R. Ambrus, Z. Aigner & P. Szabó-Révész

  2. Department of Pharmaceutical Chemistry, University of Pavia, Via Taramelli 12, 27100, Pavia, Italy

    L. Catenacci, G. Bettinetti & M. Sorrenti

Authors
  1. R. Ambrus
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  2. Z. Aigner
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  3. L. Catenacci
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  4. G. Bettinetti
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  5. P. Szabó-Révész
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  6. M. Sorrenti
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Correspondence to M. Sorrenti.

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Ambrus, R., Aigner, Z., Catenacci, L. et al. Physico-chemical characterization and dissolution properties of nifluminic acid-cyclodextrin-PVP ternary systems. J Therm Anal Calorim 104, 291–297 (2011). https://doi.org/10.1007/s10973-010-1069-1

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  • DOI: https://doi.org/10.1007/s10973-010-1069-1

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