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Synthesis of deuterium-labeled moxifloxacin

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Abstract

The stable isotope-labeled moxifloxacin was required in the clinical pharmacokinetic studies. Starting from furo[3,4-b]pyridine-5, 7-dione, a seven-step synthesis for deuterium-labeled moxifloxacin was described, and deuteriums were incorporated in positions 14, 20 of pyrrolo ring of moxifloxacin. The stable labeled moxifloxacin provided an outstanding internal standard for metabolism process studies.

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Authors and Affiliations

  1. School of Petroleum Engineering, Yangtze University, 1 Daxue Road, Caidian District, Wuhan, 430100, Hubei, People’s Republic of China

    Lei Tian

  2. School of Resources and Environment, Yangtze University, 1 Daxue Road, Caidian District, Wuhan, 430100, Hubei, People’s Republic of China

    Bo Shao & Mei He

  3. School of Biochemical and Environmental Engineering, Nanjing Xiaozhuang University, 3601 Hongjing Road, Nanjing, 211171, Jiangsu, People’s Republic of China

    Jian Li

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  1. Lei Tian
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  2. Bo Shao
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  4. Mei He
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Correspondence to Mei He.

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Tian, L., Shao, B., Li, J. et al. Synthesis of deuterium-labeled moxifloxacin. J Radioanal Nucl Chem 326, 537–541 (2020). https://doi.org/10.1007/s10967-020-07298-z

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  • DOI: https://doi.org/10.1007/s10967-020-07298-z

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