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Utilization of (p, 4n) reaction for 86Zr production with medium energy protons and development of a 86Zr → 86Y radionuclide generator

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Abstract

Utilization of (p, 4n) reaction channel for the production of medical radionuclides became very attractive with commercial availability of medium energy cyclotrons. Significantly higher yields and radionuclidic purity may open new perspectives for several novel and some of the radionuclides previously have not been considered due to production difficulties. In present work, we show the proof-of-principle study on the production of 86Y for Positron Emission Tomography imaging via radionuclide generator 86Zr → 86Y. Production suitability of 86Zr from natural yttrium target and radiochemical separation strategies were tested. In addition, two generator systems were proposed and evaluated.

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Acknowledgements

We thank the Phasotron team for performing the yttrium targets irradiations. We also thank to Dr. Steffen Happel from Triskem International for providing samples of ZR-resin.

Funding

Financial support of this project was provided by the Russian Foundation for Fundamental Research Grants (RFBR 15-53-12372), by the Program for graduate and postgraduate students in the framework of collaboration between JINR laboratories, JINR Member States and the Czech scientific institutions, by the joint Czech Republic—JINR representatives committee Grant No.: 03-2-1100-2010/2018 and Health Research Agency of the Czech Republic and the Ministry of Education Youth and Sports of the Czech Republic and the EU, grant No’s.: NV16-30544A and CAP-CZ.02.1.01/0.0/0.0/15_003/0000464. TRIUMF receives funding via a contribution agreement with the National Research Council of Canada.

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Authors and Affiliations

  1. DLNP, Joint Institute for Nuclear Research, Joliot-Curie st. 6, 141980, Dubna, Russian Federation

    Ayagoz Baimukhanova, Atanaska Marinova, Dimitr Karaivanov & Dmitry Filosofov

  2. Institute of Nuclear Physics, Ibragimov st. 1, Almaty, Kazakhstan, 050032

    Ayagoz Baimukhanova

  3. Life Sciences Division, TRIUMF, 4004 Wesbrook Mall, Vancouver, V6T 2A3, Canada

    Valery Radchenko, Victoria Brown & Paul Schaffer

  4. Department of Nuclear Chemistry, Czech Technical University in Prague, Brehova st. 7, 115 19, Prague, Czech Republic

    Ján Kozempel

  5. Institute of Microelectronics Technology and High-Purity Materials, Akademik Ossipyan st. 6, Chernogolovka, 142432, Russian Federation

    Vasily Karandashev

  6. Institute for Nuclear Research and Nuclear Energy, Tsarigradsko shose 72, 1784, Sofia, Bulgaria

    Dimitr Karaivanov

Authors
  1. Ayagoz Baimukhanova
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  2. Valery Radchenko
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  3. Ján Kozempel
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  4. Atanaska Marinova
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  5. Victoria Brown
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  6. Vasily Karandashev
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  7. Dimitr Karaivanov
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  8. Paul Schaffer
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  9. Dmitry Filosofov
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Corresponding author

Correspondence to Valery Radchenko.

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Baimukhanova, A., Radchenko, V., Kozempel, J. et al. Utilization of (p, 4n) reaction for 86Zr production with medium energy protons and development of a 86Zr → 86Y radionuclide generator. J Radioanal Nucl Chem 316, 191–199 (2018). https://doi.org/10.1007/s10967-018-5730-7

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