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Hydroxyapatite particles as carriers for 223Ra

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Abstract

Systematic investigation of optimal conditions for preparation and in vitro stability of HAP particles labeled with 223Ra, that could be considered as promising candidates for targeted α-therapy, has been carried out. Two different approaches to HAP labelling were tested: sorption of Ra2+ on pre-synthesized HAP-particles and incorporation of Ra2+ into the structure of HAP during its synthesis. Two textural forms of HAP particles were used—nanoparticles and particles with the diameter of 350 ± 20 μm. Kinetics of 223Ra sorption on HAP of different particle size and desorption in 0.9 % NaCl solution were studied. The influence of solution acidity and solid to liquid phase ratio on sorption of Ra was evaluated and the sorption yield up to 98 % was achieved. It was found that the optimal conditions for the sorption included synthesis of HAP nanoparticles in the presence of 223Ra at pH values of 4–7 followed by annealing at 900 °C. In this case subsequent cumulative desorption of Ra was <5 % of initial activity.

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References

  1. Trewartha D, Carter K (2013) Advances in prostate cancer treatment. Nat Rev Drug Discov 12:823–824

    Article  CAS  Google Scholar 

  2. Tomoda K, Ariizumi H, Nakaji T, Makino K (2010) Hydroxyapatite particles as drug carriers for proteins. Colloid Surf B 76:226–235

    Article  CAS  Google Scholar 

  3. Harrington KJ, Mohammadtah S, Uster PS, Glass D, Peters AM, Stewart JS (2001) Effective targeting of solid tumors in patients with locally advanced cancers by radiolabeled pegylated liposomes. Clin Cancer Res 7:243–254

    CAS  Google Scholar 

  4. Henriksen G, Schoultz BW, Michaelsen TE, Bruland ϴS, Larsen RH (2004) Sterically stabilized liposomes as a carrier for alpha-emitting radium and actinium radionuclides. Nucl Med Biol 31:441–449

    Article  CAS  Google Scholar 

  5. Rojas JV, Woodward JD, Chen N, Rondinone AJ, Castano CH, Mirzadeh S (2015) Synthesis and characterization of lanthanum phosphate nanoparticles as carriers for 223Ra and 225Ra for targeted alpha therapy. Nucl Med Biol 42(7):614–620

    Article  CAS  Google Scholar 

  6. Severin AV, Mazina SE, Melikhov IV (2009) Physicochemical aspects of the antiseptic action of nanohydroxyapatite. Biophysics 54(6):701–705

    Article  Google Scholar 

  7. Bohner M (2000) Calcium orthophosphates in medicine: from ceramics to calcium phosphate cements. Injury 31:D37–D47

    Article  Google Scholar 

  8. Mizushima Y, Ikoma T, Tanaka J, Hoshi K, Ishihara T, Ogawa Y, Ueno A (2006) Injectable porous hydroxyapatite microparticles as a new carrier for protein and lipophilic drugs. J Control Release 110(2):260–265

    Article  CAS  Google Scholar 

  9. Chakraborty S, Das T, Sarma HD, Venkatesh M, Banerjee S (2008) Preparation and preliminary studies on 177Lu-labeled hydroxyapatite particles for possible use in the therapy of liver cancer. Nucl Med Biol 35:589–597

    Article  CAS  Google Scholar 

  10. Albernaz MDS, Ospina CA, Rossi AM, Santos-Oliveira R (2014) Radiolabelled nanohydroxyapatite with 99mTc: perspectives to nanoradiopharmaceuticals construction. Art Cells Nanomed Biotechnol 42(2):88–91

    Article  CAS  Google Scholar 

  11. Kozempel J, Vlk M, Malkova E, Bajzıkova A, Barta J, Santos-Oliveira R, Malta Rossi A (2015) Prospective carriers of 223Ra for targeted alpha therapy. J Radioanal Nucl Chem 304:443–447

    Article  CAS  Google Scholar 

  12. National Nuclear Data Center, Brookhaven National Laboratory, USA. http://www.nndc.bnl.gov/nudat2

  13. Vasiliev AN, Ostapenko VS, Lapshina EV, Ermolaev SV, Danilov SS, Zhuikov BL, Kalmykov SN (2016) Recovery of Ra-223 from natural thorium irradiated by protons. Radiochim Acta. doi:10.1515/ract-2015-2549

    Google Scholar 

  14. Melikhov IV, Komarov VF, Severin AV, Bozhevolnov VE, Rudin VN (2000) Two-dimensional crystalline hydroxyapatite. Dokl Phys Chem 373:125–128

    Google Scholar 

  15. Suvorova EI, Klechkovskaya VV, Komarov VF, Severin AV, Melikhov IV, Buffat PA (2006) Electron microscopy of biomaterials based on hydroxyapatite. Crystallogr Rep 51(5):881–887

    Article  CAS  Google Scholar 

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Acknowledgments

This work was supported by Russian foundation for basic research with Grant No. 16-33-00200. The authors are also grateful to Steffen Happel (Triskem Int.) for providing the samples of extraction chromatographic resins for 223Ra recovery and to Boris Nedyalkov (Cardiff University, UK) for the help in preparing of the manuscript.

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Authors and Affiliations

  1. Chemistry Department, Lomonosov Moscow State University, Leninskie Gory 1, Moscow, Russia, 119991

    A. N. Vasiliev, A. Severin, E. Chernykh & S. Kalmykov

  2. Institute for Nuclear Research of Russian Academy of Sciences, 60th October Anniversary Prospect, 7a, Moscow, Russia, 117312

    A. N. Vasiliev, E. Lapshina & S. Ermolaev

  3. National Research Center “Kurchatov Institute”, Academician Kurchatov sq., 1, Moscow, Russia, 123182

    S. Kalmykov

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  1. A. N. Vasiliev
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  2. A. Severin
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  3. E. Lapshina
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  4. E. Chernykh
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  5. S. Ermolaev
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  6. S. Kalmykov
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Correspondence to A. N. Vasiliev.

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Vasiliev, A.N., Severin, A., Lapshina, E. et al. Hydroxyapatite particles as carriers for 223Ra. J Radioanal Nucl Chem 311, 1503–1509 (2017). https://doi.org/10.1007/s10967-016-5007-y

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  • DOI: https://doi.org/10.1007/s10967-016-5007-y

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