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Monitoring of gamma emission and neutron transmission during boron neutron capture treatment delivery

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Abstract

The ability to map boron and hydrogen distributions in the body is paramount to the success of boron neutron capture therapy (BNCT). We investigated treatment-time quantitative mapping of these distributions by detecting (i) 0.48 MeV de-excitation photons from neutron capture by boron-10; (ii) 2.22 MeV photons from neutron capture by hydrogen; and (iii) transmitted neutrons. Monte Carlo simulations reported no detectable difference when 10B in tumour was varied from 0 to 50 ppm, and when the tumour size was varied from 0.0 to 9.5 cm3.

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References

  1. Chin, M.P.W., Lewis, D.G., Giddy, J.G.: The Monte Carlo Method: Versatility Unbounded in a Dynamic Computing World. American Nuclear Society, Chattanooga (2005)

    Google Scholar 

  2. Spyrou, N.M.: Neutron activation analysis challenges problems and applications in biomedical and other areas. J. Radioanal. Nucl. Chem. 239, 59–70 (1999)

    Article  CAS  Google Scholar 

  3. Valda, A., Minsky, D.M., Kreiner, A.J., Burlon, A.A., Somacal, H.: Development of a tomographic system for online dose measurements in BNCT (boron neutron capture therapy)? Braz. J. Phys. 35, 785–788 (2005)

    Article  CAS  Google Scholar 

  4. Verbakel, W., Stecher-Rasmussen, F.: On-line reconstruction of low boron concentrations by in vivo gamma-ray spectroscopy for BNCT. Phys. Med. Biol. 46, 687–701 (2001)

    Article  CAS  Google Scholar 

  5. Pelowitz, D.B. MCNPX user’s manual. Los Alamos National Laboratory, Los Alamos (2005)

  6. Xu, X.G., Chao, T.C., Bozkurt, A.: VIP-man: an image-based whole-body adult male model constructed from color photographs of the visible human project for multi-particle Monte Carlo calculations. Health Phys. 78, 476–486 (2000)

    Article  CAS  Google Scholar 

  7. Chin, M.P.W., Spyrou, N.M.: In: Proceedings of 13th International Congress on Neutron Capture Therapy, Florence (2008)

  8. Bleuel, D.L., Donahue, R.J., Ludewigt, B.A., Vujic, J.: Development of a neutron energy-biased in-air figure-of-merit of predicting in-phantom BNCT neutron beam characteristics. Lawrence Berkeley National Laboratory, Berkeley (1998)

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  1. Department of Physics, University of Surrey, Guildford, Surrey, GU2 7XH, UK

    M. P. W. Chin & N. M. Spyrou

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  1. M. P. W. Chin
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  2. N. M. Spyrou
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Correspondence to N. M. Spyrou.

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Chin, M.P.W., Spyrou, N.M. Monitoring of gamma emission and neutron transmission during boron neutron capture treatment delivery. J Radioanal Nucl Chem 281, 149–152 (2009). https://doi.org/10.1007/s10967-009-0063-1

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  • DOI: https://doi.org/10.1007/s10967-009-0063-1

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