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Review on modeling anti-antibody responses to monoclonal antibodies

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Abstract

Monoclonal antibodies (mAbs) represent a therapeutic strategy that has been increasingly used in different diseases. mAbs are highly specific for their targets leading to induce specific effector functions. Despite their therapeutic benefits, the presence of immunogenic reactions is of growing concern. The immunogenicity identified as anti-drug antibodies (ADA) production due to the continuous administration of mAbs may affect the pharmacokinetics (PK) and/or the pharmacodynamics (PD) of mAbs administered to patients. Therefore, the immunogenicity and its clinical impact have been studied by several authors using PK modeling approaches. In this review, the authors try to present all those models under a unique theoretical mechanism-based framework incorporating the main considerations related to ADA formation, and how ADA may affect the efficacy or toxicity profile of some therapeutic biomolecules.

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Authors and Affiliations

  1. Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, 31080, Spain

    José David Gómez-Mantilla, Iñaki F. Trocóniz & María J. Garrido

  2. Department of Clinical Pharmacy, School of Pharmacy, University of Berlin, Berlin, Germany

    Zinnia Parra-Guillén

Authors
  1. José David Gómez-Mantilla
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  2. Iñaki F. Trocóniz
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  3. Zinnia Parra-Guillén
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  4. María J. Garrido
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Correspondence to Iñaki F. Trocóniz.

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Gómez-Mantilla, J.D., Trocóniz, I.F., Parra-Guillén, Z. et al. Review on modeling anti-antibody responses to monoclonal antibodies. J Pharmacokinet Pharmacodyn 41, 523–536 (2014). https://doi.org/10.1007/s10928-014-9367-z

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  • DOI: https://doi.org/10.1007/s10928-014-9367-z

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