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Circadian Rhythm and Pain: Mathematical Model based on Multiagent Simulation

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Abstract

The circadian rhythm is responsible for the daily variations in metabolism, and circadian rhythm disorders have direct implications for many diseases, such as obesity and mental disorders. The regulation of sleep time is the most common example of the importance of the circadian rhythm for the functioning of the human body. In this sense, this work aims to study a mathematical and computational model based on multiagent simulation that simulates the synchronization and desynchronization of the circadian rhythm in relation to the pain variables. The results from the multiagent simulation of circadian rhythms show that in relation to pain, sleep, especially its biological rhythms, is directly affected by pain. In this way, our mathematical model was able to show that pain causes changes in the circadian rhythm and it can contribute to the medical field analysis.

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Notes

  1. The model name is the union of the first letters of the authors surname.

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Funding

This study was funded by CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior) with scholarship to one of the authors.

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Authors and Affiliations

  1. Universidade Federal do Rio Grande - RS - FURG, Av. Italia s/n km 08, Rio Grande, Brazil

    Angélica T. dos Santos, Catia M. S. Machado & Diana F. Adamatti

Authors
  1. Angélica T. dos Santos
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  2. Catia M. S. Machado
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  3. Diana F. Adamatti
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Correspondence to Angélica T. dos Santos.

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The authors declare no conflict of interest.

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Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Brazilian research committee number 18147119.9.0000.5324.

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This article belongs to the Topical Collection: Healthcare Intelligent Multi-Agent Systems (HIMAS2020)

Guest Editors: Neil Vaughan, Sara Montagna, Stefano Mariani, Eloisa Vargiu and Michael I. Schumacher

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Santos, A.T.d., Machado, C.M.S. & Adamatti, D.F. Circadian Rhythm and Pain: Mathematical Model based on Multiagent Simulation. J Med Syst 44, 173 (2020). https://doi.org/10.1007/s10916-020-01622-6

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