Abstract
In this paper we present a method to solve a constrained optimal control problem to calculate the optimal enzyme concentrations in a chemical process by considering the minimization of the transition time. The method, based on Pontryagin’s Minimum Principle, allows us to obtain the generalized solution of an \(n\)-step system with an unbranched scheme and bilinear kinetic models in an almost exclusively analytical way.
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E. Klipp, R. Heinrich, H.G. Holzhutter, Prediction of temporal gene expression. Metabolic optimization by re-distribution of enzyme activities. Eur. J. Biochem. 269(22), 5406–5413 (2002)
M. Bartl, P. Li, S. Schuster, Modelling the optimal timing in metabolic pathway activation-Use of Pontryagin’s Maximum Principle and role of the Golden section. BioSystems 101, 67–77 (2010)
D. Oyarzun, B. Ingalls, R. Middleton, D. Kalamatianos, Sequential activation of metabolic pathways: a dynamic optimization approach. Bull. Math. Biol. 71(8), 1851–1872 (2009)
M. Llorens, J.C. Nuno, Y. Rodriguez, E. Melendez-Hevia, F. Montero, Generalization of the theory of transition times in metabolic pathways: a geometrical approach. Biophys. J. 77(1), 23–36 (1999)
N. Torres, Application of the transition time of metabolic systems as a criterion for optimization of metabolic processes. Biotechnol. Bioeng. 44, 291–296 (1994)
R. Vinter, Optimal Control, Systems and Control: Foundations and Applications (Birkhäuser Boston Inc., Boston, 2000)
H. Maurer, C. Buskens, J.H.R. Kim, C.Y. Kaya, Optimization methods for the verification of second order sufficient conditions for bang-bang controls. Optim. Control Appl. Meth. 26, 129–156 (2005)
A. Zaslaver, A. Mayo, R. Rosenberg, P. Bashkin, H. Sberro, M. Tsalyuk, M. Surette, U. Alon, Just-in-time transcription program in metabolic pathways. Nat. Genet. 36(5), 486–491 (2004)
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Bayón, L., Grau, J.M., Ruiz, M.M. et al. Optimal control of a linear unbranched chemical process with \(n\) steps: the quasi-analytical solution. J Math Chem 52, 1036–1049 (2014). https://doi.org/10.1007/s10910-013-0279-8
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DOI: https://doi.org/10.1007/s10910-013-0279-8