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Potentialities of Bio-functionalized Carbon Nanotubes for Different Anti-cancerous Activities

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Abstract

The utilization of carbon nanotubes (CNTs) in the field of cancer therapeutics has emerged as a promising avenue of research in recent years. This inquiry delves into the multifaceted potential of bio-functionalized carbon nanotubes for diverse anti-cancer activities. Carbon nanotubes, with their distinct structural and physicochemical properties, offer a versatile platform for innovative approaches in cancer diagnosis, treatment, and comprehension of the underlying molecular mechanisms. The process of bio-functionalizing CNTs plays a pivotal role in enhancing their compatibility with living organisms and specificity, thereby facilitating precise targeting of cancer cells. This scholarly article elucidates the strategies employed for modifying the surface of CNTs and characterizes the bio-functionalized CNTs, setting the stage for their application in anti-cancer therapies. Through a thorough examination of the anti-cancer activities, this research investigates the potential of CNTs to serve as carriers for drug delivery, exemplifying their ability to enhance the availability of drugs and mitigate side effects. Moreover, this study elucidates the diagnostic potential of bio-functionalized CNTs, explicating their applications in cancer imaging, detection, and identification of biomarkers. Mechanistically, the article unveils the pathways through which these nanotubes exert their anti-cancer effects, including the induction of apoptosis and modulation of autophagy. While acknowledging the immense promise of bio-functionalized CNTs, this research also highlights the existing challenges and limitations. Looking toward the future, this article discusses emerging trends in CNT-based cancer therapies, envisioning a future where personalized medicine and nanotechnology converge to revolutionize cancer treatment. Ethical and regulatory considerations are also deliberated upon, emphasizing the need for a responsible and safe transition of these technologies from laboratory experiments to clinical applications. In summary, this study unravels the burgeoning potential of bio-functionalized carbon nanotubes in various anti-cancer activities, underscoring their transformative impact on cancer research and therapy. As the field of nanomedicine continues to expand, these findings contribute to a deeper understanding of the possibilities that lie ahead in the battle against cancer.

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Acknowledgements

The authors express their gratitude to the Department of Biotechnology, Sathyabama Institute of Science and Technology, Chennai, as well as the International Research Centre, Centre for Nanoscience and Nanotechnology, SIST, Chennai, for conducting the research.

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  1. Department of Biotechnology, Sathyabama Institute of Science and Technology, Jeppiaar Nagar, Chennai, 600119, India

    Granap Blessy Ramesh & Prabhakar Singh

  2. Centre for Nanoscience & Nanotechnology, International Research Centre, Sathyabama Institute of Science and Technology, Jeppiaar Nagar, Chennai, 600119, India

    Kunal Biswas

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All authors made contributions to the conceptualization and design of the study. GBR: were responsible for the preparation of materials, collection and analysis of data, PS: drafted the work and revised it critically for important intellectual content and KB: drafted and approved the version to be published. The final version of the manuscript was reviewed and approved by all authors.

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Ramesh, G.B., Singh, P. & Biswas, K. Potentialities of Bio-functionalized Carbon Nanotubes for Different Anti-cancerous Activities. J Inorg Organomet Polym 34, 2325–2350 (2024). https://doi.org/10.1007/s10904-024-03012-8

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