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Two Mixed-Ligand Co(II) Coordination Polymers: Treatment Activity on COPD via Reding the Activity of the AMPK Signaling Pathway

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Abstract

Two novel coordination polymers (CPs) based on Co(II) ions as nodes {[Co2(HBTC)2(TIAB)](H2O)}n (1, TIAB = 1,2,4,5-tetrakis(1-imidazolyl)benzene, H3BTC = 1,3,5-benzenetricarboxylic acid) and {[Co3(BIMP)2(BTC)2(H2O)2]·3H2O}n (2, BIMP = 3,6-bis(imidazole-1-yl)pyridazine) are produced on the basis of the ligand H3BTC and distinct nitrogen-donor co-ligands (TIAB for the compound 1 and BIMP for the compound 2). The structural analysis results show that complex 1 has a 3D framework structure with a (4,6)-connected topological net based on the binuclear Co2 units, and complex 2 reflects a 3D framework structure with a (3,4)-connected topological net. For the treatment of the chronic obstructive pulmonary disease (COPD), their biological activities were also evaluated and the mechanism was revealed as well. Firstly, the mice model of COPD was established and compound 1 or 2 was injected for the indicated treatment. The partial pressure of carbon dioxide (PaCO2) and oxygen (PaO2) was determined by the blood gas analysis. The inflammatory cytokines release was detected by enzyme-linked immunosorbent assay (ELISA). The activation of the AMPK signaling pathway was determined by the real time reverse transcription-polymerase chain reaction (RT-PCR). Finally, the accumulation of the ROS in alveolar epithelial cells was detected with flow cytometry. Compound 1 showed stronger biological activity than compound 2 on COPD treatment.

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Authors and Affiliations

  1. Department of Infection Control, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China

    Hua Liu

  2. Department of Respiratory Medicine, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China

    Dan-Dan Tang & Xiao-Juan Yan

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  1. Hua Liu
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  2. Dan-Dan Tang
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Correspondence to Xiao-Juan Yan.

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Liu, H., Tang, DD. & Yan, XJ. Two Mixed-Ligand Co(II) Coordination Polymers: Treatment Activity on COPD via Reding the Activity of the AMPK Signaling Pathway. J Inorg Organomet Polym 31, 3793–3801 (2021). https://doi.org/10.1007/s10904-021-01996-1

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