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Agreement of an Inert Gas Rebreathing Device with Thermodilution and the Direct Oxygen Fick Method in Measurement of Pulmonary Blood Flow

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Abstract

Objective. Inert gas rebreathing is a well established method for the non-invasive measurement of pulmonary blood flow. We tested the agreement in measurement of pulmonary blood flow (Qt rb) by a new inert soluble gas rebreathing device, the Innocor (Innovision, Copenhagen), with bolus thermodilution (Qt td) and the direct oxygen Fick (Qt Fick) method. Methods. 9 patients pre- and post-cardiac surgery were recruited resulting in 20 sets of measurements overall. Arterial and mixed venous blood samples were collected simultaneously with a thermodilution measurement and rebreathing manoeuvre to measure both V O2 and effective pulmonary capillary blood flow. Results. Mean bias (95% confidence limits) was: Qt rb − Qt td 0.01 (± 0.42) L/min; Qt rb − Qt Fick + 0.34 (± 0.59) L/min. The standard deviation of the difference between paired measurements was: Qt td − Qt rb ± 0.89 L/min; Qt Fick − Qt rb ± 1.26 L/min. Conclusions. Acceptable overall agreement between the Innocor and these reference standards was demonstrated.

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Authors and Affiliations

  1. Department of Anaesthesia, Austin Hospital, Melbourne, Australia

    Philip J. Peyton MBBS, MD, FANZCA

  2. Department of Allergy, Immunology and Respiratory Medicine, The Alfred Hospital and Monash University, Melbourne

    Bruce Thompson PhD

  3. Department of Anaesthesia, Austin Hospital, 3084, Heidelberg, Melbourne, Australia

    Philip J. Peyton MBBS, MD, FANZCA

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  1. Philip J. Peyton MBBS, MD, FANZCA
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  2. Bruce Thompson PhD
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Correspondence to Philip J. Peyton MBBS, MD, FANZCA.

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Peyton, P.J., Thompson, B. Agreement of an Inert Gas Rebreathing Device with Thermodilution and the Direct Oxygen Fick Method in Measurement of Pulmonary Blood Flow. J Clin Monit Comput 18, 373–378 (2004). https://doi.org/10.1007/s10877-005-1589-6

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  • DOI: https://doi.org/10.1007/s10877-005-1589-6

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